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Comparative visualization of genotype-phenotype relationships

Nature Methods volume 12, pages 698–699 (2015)Cite this article

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A Corrigendum to this article was published on 29 October 2015

This article has been updated

To the Editor

The International Mouse Phenotyping Consortium (IMPC) aims1 to create a comprehensive functional catalog of the mammalian genome. It currently provides access to over 22 million data points concerning the knockout effects of 1,633 mouse genes on 44 classes of well-defined phenotypic traits. These data were collected2 at ten phenotyping centers worldwide. Because data are only as good as the tools available to analyze them, the IMPC has developed specialized tools3 to reliably extract useful information4 from these data.

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Figure 1: Defining features of Phenoview for comparative visualization of genotype-phenotype relationships.

Change history

  • 24 September 2015

    In the version of this article initially published, a funding source was omitted. The authors acknowledge additional funding from the Medical Research Council (program MC_U142684171). The error has been corrected in the HTML and PDF versions of the article.

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Acknowledgements

The US National Institutes of Health (NIH) funded Phenoview (U54 HG006370). The work was also funded by the Medical Research Council under program MC_U142684171. We thank the phenotyping centers for collecting the data, and EMBL-EBI for hosting the data archive.

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Authors and Affiliations

  1. MRC Harwell, Medical Research Council, Harwell, UK

    Gagarine Yaikhom, Hugh Morgan, Duncan Sneddon, Ahmad Retha, Julian Atienza-Herrero, Andrew Blake, James Brown, Armida Di Fenza, Tanja Fiegel, Neil Horner, Natalie Ring, Luis Santos, Henrik Westerberg, Steve D M Brown & Ann-Marie Mallon

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  1. Gagarine Yaikhom
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  2. Hugh Morgan
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Correspondence to Gagarine Yaikhom.

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Supplementary information

Supplementary Note

In this supplement, we first present a quick-start guide that describes the basic steps for using Phenoview, and how the raw data may be downloaded for independent analysis. (PDF 427 kb)

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Yaikhom, G., Morgan, H., Sneddon, D. et al. Comparative visualization of genotype-phenotype relationships. Nat Methods 12, 698–699 (2015). https://doi.org/10.1038/nmeth.3477

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