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Volume 12 Issue 2, February 2015

Extracellular matrix patterned in a mesh consisting of 20-μm-wide stripes of laminin (green) and fibronectin (purple) spaced 20 μm apart and overlaid conformally on high–aspect ratio microridges. Image by Q. Jallerat and J.M. Szymanski, Carnegie Mellon University. Article p134.

Editorial

  • Is social media a new 4mat 4 science in UR community? It may be time to sign up.

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This Month

  • Brainstorming leads to an invention that makes a lab workhorse gallop.

    • Vivien Marx
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  • Use inherent properties of time to create effective visualizations.

    • Marc Streit
    • Nils Gehlenborg
    This Month
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Correspondence

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Research Highlights

  • Gold supports nearly eliminate unwanted specimen motion in cryo-electron microscopy, enabling high-resolution structure determination of challenging proteins.

    • Allison Doerr
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  • An engineered dCas9–guide RNA complex containing three different transcriptional activation domains achieves consistently high expression of endogenous genes in a genome-wide screen.

    • Nicole Rusk
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  • Electrochemical sensors monitor communication between bacterial aggregates.

    • Michael Eisenstein
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Methods in Brief

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Tools in Brief

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Research Highlights

  • An expanded catalog of binary biophysical interactions between human proteins.

    • Natalie de Souza
    Research Highlights
  • A new study shows that time-resolved serial femtosecond crystallography can reveal high-resolution intermediates of photoactive yellow protein.

    • Rita Strack
    Research Highlights
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Technology Feature

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Perspective

  • A Perspective on the open-source and open-development software project Bioconductor provides an overview for prospective users and developers dealing with high-throughput data in genomics and molecular biology.

    • Wolfgang Huber
    • Vincent J Carey
    • Martin Morgan
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Brief Communication

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Article

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