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A mouse depicted on a radio-frequency transducer. The transducer activates optogenetic responses in the animal through an implanted light-delivery system. Cover by Erin Dewalt. Article p969
Some cells have a remarkable capacity to organize into tissue-like structures in vitro. As methods to enable self-organization improve, ethical aspects of some of these experiments will need to be considered.
Tiling of regulatory DNA with mutations introduced by genome editing nucleases and linking the resulting alleles to a phenotypic readout allows the precise determination of functional sequence motifs within these regions.
DeepSEA, a deep-learning algorithm trained on large-scale chromatin-profiling data, predicts chromatin effects from sequence alone, has single-nucleotide sensitivity and can predict effects of noncoding variants.
Spectrally resolved STORM (stochastic optical reconstruction microscopy) uses wide-field spectral measurements of sparsely activated single-molecule emitters to image cells labeled with fluorophores with highly overlapping emission spectra, opening the door to multiplexed super-resolution imaging.
Cycler constructs a trajectory of cell-cycle progression from fixed images of cells enabling the correlation of an individual cell's position in the cell cycle with multiple cellular readouts.
SpeedSeq is an open-source software suite offering very fast, accurate and comprehensive analysis of single-nucleotide and structural variants from whole genome sequencing data.
Small, lightweight LED implants and a radio-frequency transducer as a power source enable wireless optogenetic stimulation in the brain, spinal cord and peripheral nervous system of behaving mice.
DNA-programmed assembly of cells (DPAC) allows the reconstitution of organoid-like structures with controlled size, shape, cell-type composition and spatial heterogeneity.
An sgRNA-scoring algorithm (CRISPRscan) based on molecular features that enhance activity allows users to predict the most efficient sgRNA for in vivo targets.
Screening for tertiary-interaction responsiveness in large RNA ribozyme-aptamer libraries to ligands identifies RNA devices with improved activation ratios and ligand sensitivities.