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An artistic depiction of wholebrain imaging in larval zebrafish with lightfield microscopy. Cover design by The Research Institute of Molecular Pathology (IMP). Brief Communication p727
Expressing four factors in glioblastoma cells can induce a stem cell state, a technique that can improve our understanding of the disease and yield new therapeutic targets.
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9–based transcriptional repressors can be easily engineered to give rise to a large library of orthogonal devices for complex circuits in mammalian cells.
This paper reports the use of light-field microscopy for fast, large-scale imaging of neuronal activity in vivo. It is applied to image the entire animal in the worm and the whole brain in zebrafish.
Far-red fluorogenic probes for live-cell imaging of either actin or tubulin are described and used for super-resolution microscopy of various structures in a variety of cell types.
By combining the use of relatively large crystals and an X-ray free-electron laser, a radiation damage–free three-dimensional structure of a radiation-sensitive protein (bovine cytochrome oxidase) was solved at 1.9-Å resolution.
This paper combines cryo-electron tomography with super-resolution fluorescence microscopy for precise localization of molecular tags on a cellular or macromolecular structure, without fixation.
The transformation of individual animal images acquired from videos into unique reference fingerprints allows for robust tracking of individuals in groups and reidentification of individuals between sightings and across different videos.
A single-cell Western (scWestern) blotting technique allows quantitative measurements of up to 11 protein targets from ~2,000 individual cells in under 4 hours, expanding single-cell heterogeneity studies to the proteome.
This paper describes a single-vector strategy for flexible intersectional expression of genetically encoded reporters and tools in precisely defined cell types in the mouse.