Two approaches to serially enrich protein post-translational modifications allow the detection of multiple modifications in a single biological sample using mass spectrometry.
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References
Kim, W. et al. Mol. Cell 44, 325–340 (2011).
Udeshi, N.D. et al. Mol. Cell. Proteomics 11, 148–159 (2012).
Wagner, S.A. et al. Mol. Cell. Proteomics 10, M111.013284 (2011).
Altelaar, A.F., Munoz, J. & Heck, A.J. Nat. Rev. Genet. 14, 35–48 (2013).
López-Otín, C. & Hunter, T. Nat. Rev. Cancer 10, 278–292 (2010).
Mocciaro, A. & Rape, M. J. Cell Sci. 125, 255–263 (2012).
Du, Z. et al. Sci. Signal. 3, ra80 (2010).
Swaney, D.L. et al. Nat. Methods 10, 676–682 (2013).
Mertins, P. et al. Nat. Methods 10, 634–637 (2013).
Tipton, J.D. et al. J. Biol. Chem. 286, 25451–25458 (2011).
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Webb, K., Bennett, E. Eavesdropping on PTM cross-talk through serial enrichment. Nat Methods 10, 620–621 (2013). https://doi.org/10.1038/nmeth.2526
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DOI: https://doi.org/10.1038/nmeth.2526
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The role of ubiquitination in tumorigenesis and targeted drug discovery
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