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Inner-outer beauty: DNA-binding surface tags as cellular barcodes

Zinc-finger DNA-binding domains are expressed on the surface of cells so that the cells can be tagged with fluorescently labeled oligonucleotides, enabling many possible applications in complex cell populations.

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Figure 1: Uses of configurable receptor-ligand domains.

Katie Vicari

References

  1. Bendall, S.C. & Nolan, G.P. Nat. Biotechnol. 30, 639–647 (2012).

    Article  CAS  Google Scholar 

  2. Mali, P. et al. Nat. Methods 10, 403–406 (2013).

    Article  CAS  Google Scholar 

  3. Krutzik, P.O., Crane, J.M., Clutter, M.R. & Nolan, G.P. Nat. Chem. Biol. 4, 132–142 (2008).

    Article  CAS  Google Scholar 

  4. Bodenmiller, B. et al. Nat. Biotechnol. 30, 858–867 (2012).

    Article  CAS  Google Scholar 

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Correspondence to Garry Nolan.

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Nolan, G. Inner-outer beauty: DNA-binding surface tags as cellular barcodes. Nat Methods 10, 399–401 (2013). https://doi.org/10.1038/nmeth.2452

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