Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA.
Matan Hofree &
Department of Medicine, University of California, San Diego, La Jolla, California, USA.
John P Shen,
Hannah Carter &
Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Andrew Gross &
M.H. and T.I. conceived of and designed the approach. M.H. performed the data analysis, implemented the method and performed all computational experiments. J.P.S. assisted in characterizing clinical aspects of the cohorts and interpreting the biological implication of the resulting subtypes. H.C. assisted in analyzing the contributions of different mutation types and the functional scoring of mutations. A.G. compared resulting subtypes to other data layers. M.H., J.P.S. and T.I. wrote the manuscript. All authors approved the final version of this manuscript.
Competing financial interests
The authors declare no competing financial interests.