Method of the Year 2016

Content

• Method of the Year 2016: Epitranscriptome analysis

  Editorial29 Dec 2016 Nature Methods
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  Epitranscriptomics: mixed messages

  • Michael Eisenstein

  News Feature29 Dec 2016 Nature Methods
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  Reversible RNA modifications in meiosis and pluripotency

  • Arne Klungland
  • John Arne Dahl
  • Adam Filipczyk

  Commentary29 Dec 2016 Nature Methods
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  Epitranscriptome sequencing technologies: decoding RNA modifications

  This Review describes the latest methods for profiling common epitranscriptomic marks, their scale, resolution and ability to quantify. It also discusses remaining challenges.

  • Xiaoyu Li
  • Xushen Xiong
  • Chengqi Yi

  Review Article29 Dec 2016 Nature Methods
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  Global metabolomics

  The ability to measure the metabolome on a global scale lags behind other omics techniques.

  • Allison Doerr

  Method to Watch29 Dec 2016 Nature Methods
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  Expansion microscopy

  The changing face of super-resolution imaging

  • Rita Strack

  Method to Watch29 Dec 2016 Nature Methods
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  CRISPR targets RNA

  Having revolutionized DNA editing, CRISPR turns to RNA.

  • Nicole Rusk

  Method to Watch29 Dec 2016 Nature Methods
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  Cryo-electron tomography

  Cryo-electron tomography may facilitate in situ structural biology on a proteomic scale.

  • Allison Doerr

  Method to Watch29 Dec 2016 Nature Methods
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  Capturing microbial interactions

  New approaches will expose microbial dependencies and environmental interactions.

  • Tal Nawy

  Method to Watch29 Dec 2016 Nature Methods
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  Faster brain imaging

  Higher volumetric imaging rates shed light on the dynamics in neuronal networks.

  • Nina Vogt

  Method to Watch29 Dec 2016 Nature Methods
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  How single cells do it

  Single-cell sequencing is poised to elucidate how cells contribute to tissue function.

  • Tal Nawy

  Method to Watch29 Dec 2016 Nature Methods
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  Organoid culture

  Ex vivo organoid culture could revolutionize biology, but variability must be understood.

  • Natalie de Souza

  Method to Watch29 Dec 2016 Nature Methods