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Nature Methods' Method of the Year 2007 goes to next-generation sequencing. This series of articles showcase how these novel sequencing methods came into their own in 2007 and the incredible impact they promise to have in a variety of research applications. The Methods to Watch feature provide a glimpse and a wish list for future Methods of the Year.

Editorial

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Special Feature: Method of the Year
Method of the Year p1
doi:10.1038/nmeth1153
Abstract | Full text | PDF (52K)

News Feature

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Special Feature: Method of the Year
The year of sequencing pp11 - 14
Kelly Rae Chi
doi:10.1038/nmeth1154
Abstract | Full text | PDF (665K)

Primer

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Special Feature: Method of the Year
Primer: Sequencing—the next generation p15
Nicole Rusk & Veronique Kiermer
Published online: 19 December 2007 | doi:10.1038/nmeth1155
Abstract | Full text | PDF (349K)

Commentaries

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Special Feature: Method of the Year
Next-generation sequencing transforms today's biology pp16 - 18
Stephan C Schuster
Published online: 19 December 2007 | doi:10.1038/nmeth1156
Abstract | Full text | PDF (342K)

Special Feature: Method of the Year
Sequence census methods for functional genomics pp19 - 21
Barbara Wold & Richard M Myers
Published online: 19 December 2007 | doi:10.1038/nmeth1157
Abstract | Full text | PDF (416K)

Methods to Watch

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Special Feature: Method of the Year
Seeing fluorescence at super-resolution p22
Daniel Evanko
doi:10.1038/nmeth1158
Abstract | Full text | PDF (606K)

Special Feature: Method of the Year
Experimental micro-matchmaking p22
Nicole Rusk
doi:10.1038/nmeth1159
Abstract | Full text | PDF (606K)

Special Feature: Method of the Year
Structural analysis of macromolecular assemblies p23
Allison Doerr
doi:10.1038/nmeth1160
Abstract | Full text | PDF (132K)

Special Feature: Method of the Year
Controlling cells with light p23
Daniel Evanko
doi:10.1038/nmeth1161
Abstract | Full text | PDF (132K)

Special Feature: Method of the Year
Top-down mass spectrometry p24
Allison Doerr
doi:10.1038/nmeth1162
Abstract | Full text | PDF (322K)

Special Feature: Method of the Year
Induced pluripotency in human cells p24
Natalie de Souza
doi:10.1038/nmeth1163
Abstract | Full text | PDF (322K)

Special Feature: Method of the Year
Watching single molecules in cells p25
Daniel Evanko
doi:10.1038/nmeth1164
Abstract | Full text | PDF (237K)