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Supplement | 30 March 2011

Single-cell Analysis

In a series of commissioned pieces, authors discuss methods for the analysis of single cells and consider technical developments still needed.
Supplement | 01 March 2010

Visualizing Biological Data

A series of five commissioned Reviews discuss the challenges of visualizing biological data and the visualization tools available to biologists working with genomes, alignments and phylogenies, macromolecular structures, images and systems biology data.
Supplement | 15 October 2009

Next-generation sequencing data analysis

A commissioned Perspective discusses the strength and challenges of next-generation sequencing, and a series of commissioned Reviews explain the principles behind data-analysis software for important applications from alignment and assembly to structural-variant detection and the interpretation of ChIP-seq and RNA-seq data.