Image: Michael W. Mullowney. Cover Design: Erin Dewalt.

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Latest Research

  • Resource |

    This Resource describes genetic tools for microbial eukaryotes, providing a roadmap for developing genetically tractable organisms.

    • Drahomíra Faktorová
    • , R. Ellen R. Nisbet
    • , José A. Fernández Robledo
    • , Elena Casacuberta
    • , Lisa Sudek
    • , Andrew E. Allen
    • , Manuel Ares Jr
    • , Cristina Aresté
    • , Cecilia Balestreri
    • , Adrian C. Barbrook
    • , Patrick Beardslee
    • , Sara Bender
    • , David S. Booth
    • , François-Yves Bouget
    • , Chris Bowler
    • , Susana A. Breglia
    • , Colin Brownlee
    • , Gertraud Burger
    • , Heriberto Cerutti
    • , Rachele Cesaroni
    • , Miguel A. Chiurillo
    • , Thomas Clemente
    • , Duncan B. Coles
    • , Jackie L. Collier
    • , Elizabeth C. Cooney
    • , Kathryn Coyne
    • , Roberto Docampo
    • , Christopher L. Dupont
    • , Virginia Edgcomb
    • , Elin Einarsson
    • , Pía A. Elustondo
    • , Fernan Federici
    • , Veronica Freire-Beneitez
    • , Nastasia J. Freyria
    • , Kodai Fukuda
    • , Paulo A. García
    • , Peter R. Girguis
    • , Fatma Gomaa
    • , Sebastian G. Gornik
    • , Jian Guo
    • , Vladimír Hampl
    • , Yutaka Hanawa
    • , Esteban R. Haro-Contreras
    • , Elisabeth Hehenberger
    • , Andrea Highfield
    • , Yoshihisa Hirakawa
    • , Amanda Hopes
    • , Christopher J. Howe
    • , Ian Hu
    • , Jorge Ibañez
    • , Nicholas A. T. Irwin
    • , Yuu Ishii
    • , Natalia Ewa Janowicz
    • , Adam C. Jones
    • , Ambar Kachale
    • , Konomi Fujimura-Kamada
    • , Binnypreet Kaur
    • , Jonathan Z. Kaye
    • , Eleanna Kazana
    • , Patrick J. Keeling
    • , Nicole King
    • , Lawrence A. Klobutcher
    • , Noelia Lander
    • , Imen Lassadi
    • , Zhuhong Li
    • , Senjie Lin
    • , Jean-Claude Lozano
    • , Fulei Luan
    • , Shinichiro Maruyama
    • , Tamara Matute
    • , Cristina Miceli
    • , Jun Minagawa
    • , Mark Moosburner
    • , Sebastián R. Najle
    • , Deepak Nanjappa
    • , Isabel C. Nimmo
    • , Luke Noble
    • , Anna M. G. Novák Vanclová
    • , Mariusz Nowacki
    • , Isaac Nuñez
    • , Arnab Pain
    • , Angela Piersanti
    • , Sandra Pucciarelli
    • , Jan Pyrih
    • , Joshua S. Rest
    • , Mariana Rius
    • , Deborah Robertson
    • , Albane Ruaud
    • , Iñaki Ruiz-Trillo
    • , Monika A. Sigg
    • , Pamela A. Silver
    • , Claudio H. Slamovits
    • , G. Jason Smith
    • , Brittany N. Sprecher
    • , Rowena Stern
    • , Estienne C. Swart
    • , Anastasios D. Tsaousis
    • , Lev Tsypin
    • , Aaron Turkewitz
    • , Jernej Turnšek
    • , Matus Valach
    • , Valérie Vergé
    • , Peter von Dassow
    • , Tobias von der Haar
    • , Ross F. Waller
    • , Lu Wang
    • , Xiaoxue Wen
    • , Glen Wheeler
    • , April Woods
    • , Huan Zhang
    • , Thomas Mock
    • , Alexandra Z. Worden
    •  & Julius Lukeš
  • Article |

    Light-dependent variants of Cre, Dre and Flp enable targeted sparse or single-cell labeling in mouse and zebrafish.

    • Shenqin Yao
    • , Peng Yuan
    • , Ben Ouellette
    • , Thomas Zhou
    • , Marty Mortrud
    • , Pooja Balaram
    • , Soumya Chatterjee
    • , Yun Wang
    • , Tanya L. Daigle
    • , Bosiljka Tasic
    • , Xiuli Kuang
    • , Hui Gong
    • , Qingming Luo
    • , Shaoqun Zeng
    • , Andrew Curtright
    • , Ajay Dhaka
    • , Anat Kahan
    • , Viviana Gradinaru
    • , Radosław Chrapkiewicz
    • , Mark Schnitzer
    • , Hongkui Zeng
    •  & Ali Cetin
  • Article |

    A set of isobaric labeling reagents called TMTpro enables deep quantitative comparisons of proteome measurements across 16 samples.

    • Jiaming Li
    • , Jonathan G. Van Vranken
    • , Laura Pontano Vaites
    • , Devin K. Schweppe
    • , Edward L. Huttlin
    • , Chris Etienne
    • , Premchendar Nandhikonda
    • , Rosa Viner
    • , Aaron M. Robitaille
    • , Andrew H. Thompson
    • , Karsten Kuhn
    • , Ian Pike
    • , Ryan D. Bomgarden
    • , John C. Rogers
    • , Steven P. Gygi
    •  & Joao A. Paulo

News & Comment

Collection

Expanding the CRISPR Toolbox

The CRISPR-Cas9 system is best known for its ability to knock out or replace specific genes, via targeted cleavage of the genome. But scientists are developing many more applications, typically by using an inactive Cas9 to target other enzymes to specific genomic sites. From transcriptional regulation to base editing, these developments are extending the range of biological questions that can be probed with CRISPR/Cas9.

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