Erin Dewalt

Method of the Year 2018: Imaging in freely behaving animals

Latest Research

  • Brief Communication |

    A single-photon detector array enables robust and versatile image scanning microscopy (ISM) on any confocal microscope. This implementation makes super-resolution FLIM possible and eases a transition from confocal microscopy to ISM.

    • Marco Castello
    • , Giorgio Tortarolo
    • , Mauro Buttafava
    • , Takahiro Deguchi
    • , Federica Villa
    • , Sami Koho
    • , Luca Pesce
    • , Michele Oneto
    • , Simone Pelicci
    • , Luca Lanzanó
    • , Paolo Bianchini
    • , Colin J. R. Sheppard
    • , Alberto Diaspro
    • , Alberto Tosi
    •  & Giuseppe Vicidomini
  • Brief Communication |

    A protocol adapted to xeno- and feeder-free conditions is shown to generate reliable and consistent cortical brain organoids across differentiations and source stem cell lines, making it suitable for disease modeling and other applications.

    • Se-Jin Yoon
    • , Lubayna S. Elahi
    • , Anca M. Pașca
    • , Rebecca M. Marton
    • , Aaron Gordon
    • , Omer Revah
    • , Yuki Miura
    • , Elisabeth M. Walczak
    • , Gwendolyn M. Holdgate
    • , H. Christina Fan
    • , John R. Huguenard
    • , Daniel H. Geschwind
    •  & Sergiu P. Pașca
  • Article |

    LEAP is a deep-learning-based approach for the analysis of animal pose. LEAP’s graphical user interface facilitates training of the deep network. The authors illustrate the method by analyzing Drosophila and mouse behavior.

    • Talmo D. Pereira
    • , Diego E. Aldarondo
    • , Lindsay Willmore
    • , Mikhail Kislin
    • , Samuel S.-H. Wang
    • , Mala Murthy
    •  & Joshua W. Shaevitz
  • Article |

    A transcriptional analysis of kidney organoids reveals batch effects as the key drivers of variation, mainly through differences in maturity, and provides a list of highly variable genes and a method for estimating differentiation stage for improved disease modeling.

    • Belinda Phipson
    • , Pei X. Er
    • , Alexander N. Combes
    • , Thomas A. Forbes
    • , Sara E. Howden
    • , Luke Zappia
    • , Hsan-Jan Yen
    • , Kynan T. Lawlor
    • , Lorna J. Hale
    • , Jane Sun
    • , Ernst Wolvetang
    • , Minoru Takasato
    • , Alicia Oshlack
    •  & Melissa H. Little

News & Comment

  • This Month |

    How AI can help track animals and why breakfast powers collaboration.

    • Vivien Marx
  • Research Highlight |

    A vesicle-based mass spectrometry method enables the analysis of protein complexes in native membranes.

    • Karin Kuehnel
  • Method to Watch |

    Genetically encoded neurotransmitter sensors will shed light on neuronal communication.

    • Nina Vogt
  • Comment |

    Developments in imaging tools are making it possible to record activity from both large neuronal populations and subcellular components in freely moving animals. Although these developments are enabling relationships between brain activity and complex behaviors to be explored, many challenges need to be overcome before the potential of the freely moving animal can be fully utilized.

    • Damian J. Wallace
    •  & Jason N. D. Kerr

Nature events Directory