A proximity-tagging system to identify membrane protein–protein interactions

Latest Research

  • Resource |

    A CHO cell library displaying a near-complete repertoire of glycosaminoglycan (GAG) modifications provides a resource for cell-based binding assays, recombinant proteoglycan expression, and assembly of GAG glycan microarrays.

    • Yen-Hsi Chen
    • , Yoshiki Narimatsu
    • , Thomas M. Clausen
    • , Catarina Gomes
    • , Richard Karlsson
    • , Catharina Steentoft
    • , Charlotte B. Spliid
    • , Tobias Gustavsson
    • , Ali Salanti
    • , Andrea Persson
    • , Anders Malmström
    • , Daniel Willén
    • , Ulf Ellervik
    • , Eric P. Bennett
    • , Yang Mao
    • , Henrik Clausen
    •  & Zhang Yang
  • Article |

    Spinal cord neural stem cells are generated from human pluripotent stem cells via a chemically defined, xeno-free method, and exhibit efficient and functional engraftment in rat spinal cord lesions.

    • Hiromi Kumamaru
    • , Ken Kadoya
    • , Andrew F. Adler
    • , Yoshio Takashima
    • , Lori Graham
    • , Giovanni Coppola
    •  & Mark H. Tuszynski
  • Brief Communication |

    Single DNA molecules can be detected in aqueous solutions at ambient temperatures by electron spin resonance spectroscopy with diamond sensors.

    • Fazhan Shi
    • , Fei Kong
    • , Pengju Zhao
    • , Xiaojun Zhang
    • , Ming Chen
    • , Sanyou Chen
    • , Qi Zhang
    • , Mengqi Wang
    • , Xiangyu Ye
    • , Zhecheng Wang
    • , Zhuoyang Qin
    • , Xing Rong
    • , Jihu Su
    • , Pengfei Wang
    • , Peter Z. Qin
    •  & Jiangfeng Du
  • Brief Communication |

    Annotated image data are required for image analysis, to test analytical methods, and to train learning algorithms. This paper describes and characterizes a tool that allows researchers to crowdsource image-annotation tasks.

    • Alex J. Hughes
    • , Joseph D. Mornin
    • , Sujoy K. Biswas
    • , Lauren E. Beck
    • , David P. Bauer
    • , Arjun Raj
    • , Simone Bianco
    •  & Zev J. Gartner
  • Article |

    Humanized mouse models are useful for studies of human hematopoiesis and immunity. Li et al. report an improved model that harbors lymph nodes and therefore permits investigation of local human adaptive immune processes in secondary lymphoid tissue.

    • Yan Li
    • , Guillemette Masse-Ranson
    • , Zacarias Garcia
    • , Timothée Bruel
    • , Ayrin Kök
    • , Helene Strick-Marchand
    • , Gregory Jouvion
    • , Nicolas Serafini
    • , Ai Ing Lim
    • , Mathilde Dusseaux
    • , Thierry Hieu
    • , Franck Bourgade
    • , Antoine Toubert
    • , Daniela Finke
    • , Olivier Schwartz
    • , Philippe Bousso
    • , Hugo Mouquet
    •  & James P. Di Santo

News & Comment

Nature events Directory