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Nature Materials 8, 447–448 (1 June 2009) | doi:10.1038/nmat2456
Drug delivery: Old polymer learns new tracts
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Abstract
Since the Nobel prize-winning work of Fire and Mello a little more than ten years ago, gene silencing by means of short interfering RNA (siRNA) has been of substantial interest, particularly in the treatment and prevention of diseases. Despite numerous advances in the delivery of therapeutic siRNA, the development of siRNA delivery vehicles that are both effective and non-toxic remains a key challenge in modern medicine.
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