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Letter

Nature Materials 6, 424–428 (1 June 2007) | doi:10.1038/nmat1907

Tuneable elastomeric nanochannels for nanofluidic manipulation

Dongeun Huh , K. L. Mills , Xiaoyue Zhu , Mark A. Burns , M. D. Thouless & Shuichi Takayama

Fluidic transport through nanochannels offers new opportunities to probe fundamental nanoscale transport phenomena and to develop tools for manipulating DNA, proteins, small molecules and nanoparticles. The small size of nanofabricated devices and the accompanying increase in the effect of surface forces, however, pose challenges in designing and fabricating flexible nanofluidic systems that can dynamically adjust their transport characteristics according to the handling needs of various molecules and nanoparticles.