Article abstract
Nature Materials 6, 385 - 392 (2007)
Published online: 15 April 2007 | doi:10.1038/nmat1890
Subject Categories: Polymers | Biological materials | Biomedical materials
Multifunctional chondroitin sulphate for cartilage tissue–biomaterial integration
Dong-An Wang1,2, Shyni Varghese1, Blanka Sharma1,3, Iossif Strehin1, Sara Fermanian1,3, Justin Gorham4, D. Howard Fairbrother4, Brett Cascio5 & Jennifer H. Elisseeff1,5
Abstract
A biologically active, high-strength tissue adhesive is needed for numerous medical applications in tissue engineering and regenerative medicine. Integration of biomaterials or implants with surrounding native tissue is crucial for both immediate functionality and long-term performance of the tissue. Here, we use the biopolymer chondroitin sulphate (CS), one of the major components of cartilage extracellular matrix, to develop a novel bioadhesive that is readily applied and acts quickly. CS was chemically functionalized with methacrylate and aldehyde groups on the polysaccharide backbone to chemically bridge biomaterials and tissue proteins via a twofold covalent link. Three-dimensional hydrogels (with and without cells) bonded to articular cartilage defects. In in vitro and in vivo functional studies this approach led to mechanical stability of the hydrogel and tissue repair in cartilage defects.
- Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
- Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457
- Cartilix, Inc., Foster City, California 94404, USA
- Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA
- Department of Orthopedics, Johns Hopkins Medical School, Baltimore, Maryland 21218, USA
Correspondence to: Jennifer H. Elisseeff1,5 e-mail: jhe@jhu.edu
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