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Modelling polycystic kidney disease

Nature Materials volume 16, pages 1058–1059 (2017)Cite this article

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Cysts were generated from organoids in vitro and the removal of adherent cues was shown to play a key role in polycystic kidney disease progression. These cysts resembled those of diseased tissue phenotypically and were capable of remodelling their microenvironment.

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Figure 1: Autosomal dominant polycystic kidney disease (ADPKD) and in vitro disease models.

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Authors and Affiliations

  1. the Department of Biomedical and Experimental Sciences 'Mario Serio', and at the Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), and the Pediatric Nephrology Unit, Meyer Children's Hospital, University of Florence, Florence, 50139, Italy

    Paola Romagnani

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  1. Paola Romagnani
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Correspondence to Paola Romagnani.

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Romagnani, P. Modelling polycystic kidney disease. Nature Mater 16, 1058–1059 (2017). https://doi.org/10.1038/nmat5013

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