Pliable gels of fibrin, a fibrous protein involved in blood clotting and linked to cancer, select cells with high in vivo aggressiveness and 'stemness' from a pool of cancer cells.
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References
Liu, J. et al. Nature Mater. 11, 734–741 (2012).
Lapidot, T. et al. Nature 367, 645–648 (1994).
Quintana, E. et al. Nature 456, 593–598 (2008).
Soofi, S. S., Last, J. A., Liliensiek, S. J., Nealey, P. F. & Murphy, C. J. J. Struct. Biol. 167, 216–219 (2009).
Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Cell 126, 677–689 (2006).
Murrell, M., Kamm, R. & Matsudaira, P. Biophys. J. 101, 297–306 (2011).
Trappmann, B. et al. Nature Mater. 11, 642–649 (2012).
Engler, A. J. et al. J. Cell Biol. 166, 877–887 (2004).
Gilbert, P. M. et al. Science 329, 1078–1081 (2010).
Winer, J. P., Janmey, P. A., McCormick, M. E. & Funaki, M. Tissue Eng. Part A 15, 147–154 (2009).
Shin, J. W., Swift, J., Spinler, K. R. & Discher, D. E. Proc. Natl Acad. Sci. USA 108, 11458–11463 (2011).
Chowdhury, F. et al. Nature Mater. 9, 82–88 (2009).
Paszek, M. J. et al. Cancer Cell 8, 241–254 (2005).
Brown, A. E., Litvinov, R. I., Discher, D. E., Purohit, P. K. & Weisel, J. W. Science 325, 741–744 (2009).
Hu, Y. & Smyth, G. K. J. Immunol. Methods 347, 70–78 (2009).
Kakkar, A. K. & Macbeth, F. Br. J. Cancer 102, S24–S29 (2010).
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Shin, JW., Discher, D. Soft gels select tumorigenic cells. Nature Mater 11, 662–663 (2012). https://doi.org/10.1038/nmat3388
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DOI: https://doi.org/10.1038/nmat3388