The spreading and differentiation of stem cells depends on the stiffness of the extracellular matrix. Now, experiments on human epidermal and mesenchymal stem cells cultured on substrates with covalently attached collagen fibres show that the cells sense and respond to the anchoring of the collagen fibres to the substrate.
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Chaudhuri, O., Mooney, D. Anchoring cell-fate cues. Nature Mater 11, 568–569 (2012). https://doi.org/10.1038/nmat3366
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DOI: https://doi.org/10.1038/nmat3366
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