Stem cells that are cultured in the laboratory differentiate in response to the mechanical properties of the substrate and its topography. It is now shown that mesenchymal stem cell multipotency is prolonged when the cells are cultured on a surface patterned with an ordered arrangement of nanoscale pits.
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Mrksich, M. Multipotency retained. Nature Mater 10, 559–560 (2011). https://doi.org/10.1038/nmat3086
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DOI: https://doi.org/10.1038/nmat3086
