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  • Article |

    Nanoformulated long-acting cabotegravir prodrugs are shown to be capable of extending the native drug’s antiretroviral activity, biodistribution and pharmacokinetics for up to 12 months in mice and rhesus macaques.

    • Tanmay A. Kulkarni
    • , Aditya N. Bade
    • , Brady Sillman
    • , Bhagya Laxmi Dyavar Shetty
    • , Melinda S. Wojtkiewicz
    • , Nagsen Gautam
    • , James R. Hilaire
    • , Sruthi Sravanam
    • , Adam Szlachetka
    • , Benjamin G. Lamberty
    • , Brenda M. Morsey
    • , Howard S. Fox
    • , Yazen Alnouti
    • , JoEllyn M. McMillan
    • , R. Lee Mosley
    • , Jane Meza
    • , Paul L. Domanico
    • , Tai-Yuen Yue
    • , Gary Moore
    • , Benson J. Edagwa
    •  & Howard E. Gendelman

  • Why it Matters |

    Litao Sun, Yongming Tang and Wei Zuo reflect on their experience of nationwide distance learning in China’s universities during the COVID-19 outbreak.

    • Litao Sun
    • , Yongming Tang
    •  & Wei Zuo

  • Article |

    Dendrite formation during electrodeposition while charging lithium metal batteries compromises their safety. Solid-ion conductors are now designed with a universal chemomechanical approach, resulting in either pressure- or density-driven dendrite-suppressing properties.

    • Chengyin Fu
    • , Victor Venturi
    • , Jinsoo Kim
    • , Zeeshan Ahmad
    • , Andrew W. Ells
    • , Venkatasubramanian Viswanathan
    •  & Brett A. Helms

  • Article |

    The polarity of primary hepatocytes has now been shown to be inducible at the single-cell level by passive artificial micro-niches, indicating that the early development of polarity occurs largely independently of the types and response of the neighbouring cells.

    • Yue Zhang
    • , Richard De Mets
    • , Cornelia Monzel
    • , Vidhyalakshmi Acharya
    • , Pearlyn Toh
    • , Jasmine Fei Li Chin
    • , Noémi Van Hul
    • , Inn Chuan Ng
    • , Hanry Yu
    • , Soon Seng Ng
    • , S. Tamir Rashid
    •  & Virgile Viasnoff

  • Comment |

    New evidence suggests that the mechanism of nanoparticle entry into solid tumours may be driven by an active process. This insight paves the way for approaches to enhance the efficiency of nanomedicine delivery by harnessing active transport mechanisms, and encourage researchers to rethink how tumours are treated.

    • Subehndu Pandit
    • , Debapriya Dutta
    •  & Shuming Nie

  • News & Views |

    Finding a competitor for diamond as a good heat conductor remains challenging. Measurements on crystals of cubic boron nitride demonstrate a thermal conductivity of 1,600 W m−1 K−1 at room temperature, rivalling diamond.

    • Ashutosh Giri
    •  & Patrick E. Hopkins

  • News & Views |

    New evidence now suggests that the dominant mechanism of extravasation of nanoparticles into solid tumours may be through an active process of endothelial transcytosis.

    • Irene de Lázaro
    •  & David J. Mooney

  • News & Views |

    Two studies shed light on quantum defects in two-dimensional hexagonal boron nitride, identifying an optically addressable spin centre at room temperature and offering microscopic insights into different classes of single-photon emitters.

    • M. E. Turiansky
    • , A. Alkauskas
    •  & C. G. Van de Walle

  • Editorial |

    A collective effort from materials scientists, life scientists and clinicians is required to systematically address fundamental questions in the mechanisms of nanoparticle delivery in order to overcome the hurdles in translating nanomedicines for tumour therapy.

  • Letter |

    Flexoelectricity is the ability of materials to generate electricity upon bending. Here it is demonstrated that adding light to mechanical oscillation enhances effective flexoelectric coefficients by orders of magnitude, with the halide perovskites showing the largest coefficients.

    • Longlong Shu
    • , Shanming Ke
    • , Linfeng Fei
    • , Wenbin Huang
    • , Zhiguo Wang
    • , Jinhui Gong
    • , Xiaoning Jiang
    • , Li Wang
    • , Fei Li
    • , Shuijin Lei
    • , Zhenggang Rao
    • , Yangbo Zhou
    • , Ren-Kui Zheng
    • , Xi Yao
    • , Yu Wang
    • , Massimiliano Stengel
    •  & Gustau Catalan

  • Article |

    Developing cheap and sustainable aqueous electrolytes with a wide voltage window is key to achieving safe and high-energy Li-ion batteries. An electrolyte using the polymer poly(ethylene glycol) as a crowding agent to decrease water activity achieves a wide operation window at low salt concentration.

    • Jing Xie
    • , Zhuojian Liang
    •  & Yi-Chun Lu

  • News & Views |

    The lifetime of plasmonic excitations in semiconducting carbon nanotubes is found to strongly depend on the carrier density, offering a platform to study non-conventional one-dimensional electron dynamics and realize integrated nanophotonic devices.

    • Leonid I. Glazman

  • Review Article |

    Organic semiconductors are making their way into applications ranging from display technology to flexible electronics and biomedical applications. This Review discusses current understanding of charge carrier transport in these materials and strategies to improve their performance.

    • Simone Fratini
    • , Mark Nikolka
    • , Alberto Salleo
    • , Guillaume Schweicher
    •  & Henning Sirringhaus

  • Letter |

    The spectral range of long-lived and confined phonon polaritons in a polar van der Waals crystal is shown to be tunable by intercalation of Na atoms, expanding their potential for nanophotonic applications in the mid-infrared domain.

    • Javier Taboada-Gutiérrez
    • , Gonzalo Álvarez-Pérez
    • , Jiahua Duan
    • , Weiliang Ma
    • , Kyle Crowley
    • , Iván Prieto
    • , Andrei Bylinkin
    • , Marta Autore
    • , Halyna Volkova
    • , Kenta Kimura
    • , Tsuyoshi Kimura
    • , M.-H. Berger
    • , Shaojuan Li
    • , Qiaoliang Bao
    • , Xuan P. A. Gao
    • , Ion Errea
    • , Alexey Y. Nikitin
    • , Rainer Hillenbrand
    • , Javier Martín-Sánchez
    •  & Pablo Alonso-González

  • Article |

    A number of grain boundary phenomena in ionic materials, such as anomalous charge transport, have been attributed to space charge effects. Space charge potential at grain boundaries in lightly doped, high-purity ceria is now shown to vary by almost an order of magnitude.

    • Xin Xu
    • , Yuzi Liu
    • , Jie Wang
    • , Dieter Isheim
    • , Vinayak P. Dravid
    • , Charudatta Phatak
    •  & Sossina M. Haile

  • Article |

    Two-dimensional transition metal carbides and nitrides, known as MXenes, are currently considered as energy storage materials. A generic Lewis acidic etching route for preparing high-rate negative-electrode MXenes with enhanced electrochemical performance in non-aqueous electrolyte is now proposed.

    • Youbing Li
    • , Hui Shao
    • , Zifeng Lin
    • , Jun Lu
    • , Liyuan Liu
    • , Benjamin Duployer
    • , Per O. Å. Persson
    • , Per Eklund
    • , Lars Hultman
    • , Mian Li
    • , Ke Chen
    • , Xian-Hu Zha
    • , Shiyu Du
    • , Patrick Rozier
    • , Zhifang Chai
    • , Encarnacion Raymundo-Piñero
    • , Pierre-Louis Taberna
    • , Patrice Simon
    •  & Qing Huang

  • Article |

    Electric-field tunable plasmonic excitations in semiconducting carbon nanotubes are shown to behave consistently with the nonlinear Luttinger liquid theory, providing a platform to study non-conventional one-dimensional electron dynamics and realize integrated nanophotonic devices.

    • Sheng Wang
    • , Sihan Zhao
    • , Zhiwen Shi
    • , Fanqi Wu
    • , Zhiyuan Zhao
    • , Lili Jiang
    • , Kenji Watanabe
    • , Takashi Taniguchi
    • , Alex Zettl
    • , Chongwu Zhou
    •  & Feng Wang

  • News & Views |

    Large-scale atomically thin metals can be stabilized through confinement epitaxy at graphene/SiC interface, which exhibit a gradient bonding type and are air stable, providing a compelling platform for quantum and optoelectronic technologies.

    • Claire Berger
    •  & Walt A. de Heer

  • Editorial |

    An arsenal of spectroscopic and microscopic methods is essential to the understanding and development of quantum materials.

  • News & Views |

    Nanoresolved imaging and ultrafast laser excitation are integrated to probe and control a photoinduced hidden state in a strained manganite film.

    • Nan-Lin Wang

  • Why it Matters |

    Now more than ever before, it is vitally important for scientists, clinicians and policymakers to communicate the significance of vaccination to the public in order to counteract the spread of misinformation.

    • Tonia M. Thomas
    •  & Andrew J. Pollard

  • News & Views |

    Mutations in lamins in skeletal muscle cells have been shown to reduce nuclear stability, increase nuclear envelope rupture, and induce DNA damage and cell death. New research shows that limiting mechanical loads can rescue myofibre function and viability.

    • Joel C. Eissenberg
    •  & Susana Gonzalo

  • News & Views |

    Magnetite crystals form by the aggregation and subsequent merger of crystalline precursors, which can be interpreted in terms of colloidal assembly.

    • Jeffrey D. Rimer

  • Article |

    Counter-propagating chiral edge states are demonstrated in a photonic structure able to effectively incorporate fermionic time-reversal symmetry, thus providing the photonic implementation of an electronic topological insulator.

    • Lukas J. Maczewsky
    • , Bastian Höckendorf
    • , Mark Kremer
    • , Tobias Biesenthal
    • , Matthias Heinrich
    • , Andreas Alvermann
    • , Holger Fehske
    •  & Alexander Szameit

  • Article |

    Bi2TeI is identified as a dual topological insulator. It is a weak topological insulator with metallic states at the (010) surfaces and a topological crystalline insulator at the (001) surfaces.

    • Nurit Avraham
    • , Abhay Kumar Nayak
    • , Aviram Steinbok
    • , Andrew Norris
    • , Huixia Fu
    • , Yan Sun
    • , Yanpeng Qi
    • , Lin Pan
    • , Anna Isaeva
    • , Alexander Zeugner
    • , Claudia Felser
    • , Binghai Yan
    •  & Haim Beidenkopf

  • Article |

    Vectorial electromagnetic modes in coupled metallic nanolasers are used to emulate the behaviour of complex magnetic materials, providing an integrated nanophotonic platform to study spin exchange interactions and map large-scale optimization problems.

    • Midya Parto
    • , William Hayenga
    • , Alireza Marandi
    • , Demetrios N. Christodoulides
    •  & Mercedeh Khajavikhan

  • Article |

    Internal ion-gated organic electrochemical transistors operating in enhancement mode are shown to record electrophysiological signals in vivo, with a speed and sensitivity that enable the detection of action potentials from individual neurons.

    • Claudia Cea
    • , George D. Spyropoulos
    • , Patricia Jastrzebska-Perfect
    • , José J. Ferrero
    • , Jennifer N. Gelinas
    •  & Dion Khodagholy

  • Letter |

    NiCoFeGa single crystals exhibit large non-hysteretic superelasticity over broad temperature and composition ranges. It is attributed to the continuous phase transition with applied stress, which is related to the fluctuation of entangled ordered and disordered crystal structures.

    • Haiyang Chen
    • , Yan-Dong Wang
    • , Zhihua Nie
    • , Runguang Li
    • , Daoyong Cong
    • , Wenjun Liu
    • , Feng Ye
    • , Yuzi Liu
    • , Peiyu Cao
    • , Fuyang Tian
    • , Xi Shen
    • , Richeng Yu
    • , Levente Vitos
    • , Minghe Zhang
    • , Shilei Li
    • , Xiaoyi Zhang
    • , Hong Zheng
    • , J. F. Mitchell
    •  & Yang Ren

  • News & Views |

    A high-speed, high-gain enhancement-mode ion-gated transistor shows promise for low-power chronically implanted bioelectronic systems.

    • Scott Keene
    •  & Yoeri van de Burgt

  • Article |

    Single-crystal 2D metals are stabilized at the interface between epitaxial graphene and silicon carbide, with strong internal gradients in bonding character. The confined 2D metals demonstrate compelling superconducting properties.

    • Natalie Briggs
    • , Brian Bersch
    • , Yuanxi Wang
    • , Jue Jiang
    • , Roland J. Koch
    • , Nadire Nayir
    • , Ke Wang
    • , Marek Kolmer
    • , Wonhee Ko
    • , Ana De La Fuente Duran
    • , Shruti Subramanian
    • , Chengye Dong
    • , Jeffrey Shallenberger
    • , Mingming Fu
    • , Qiang Zou
    • , Ya-Wen Chuang
    • , Zheng Gai
    • , An-Ping Li
    • , Aaron Bostwick
    • , Chris Jozwiak
    • , Cui-Zu Chang
    • , Eli Rotenberg
    • , Jun Zhu
    • , Adri C. T. van Duin
    • , Vincent Crespi
    •  & Joshua A. Robinson

  • News & Views |

    Scanning atomic electron tomography measurements reveal the 3D local structure around single dopant atoms in 2D transition metal dichalcogenides, providing essential information to investigate and predict their electronic properties.

    • Angus I. Kirkland

  • Article |

    Here, using an interfacial growth strategy, UiO-66 MOF nanocrystals are asymmetrically embedded into conical pores in a polymer membrane. These pores have a pH-tunable mono/divalent cation selectivity of 103 102–104 and act as ionic rectifiers.

    • Jun Lu
    • , Huacheng Zhang
    • , Jue Hou
    • , Xingya Li
    • , Xiaoyi Hu
    • , Yaoxin Hu
    • , Christopher D. Easton
    • , Qinye Li
    • , Chenghua Sun
    • , Aaron W. Thornton
    • , Matthew R. Hill
    • , Xiwang Zhang
    • , Gengping Jiang
    • , Jefferson Zhe Liu
    • , Anita J. Hill
    • , Benny D. Freeman
    • , Lei Jiang
    •  & Huanting Wang

  • News & Views |

    Low-electron-dose liquid-cell transmission electron microscopy reveals a two-step nucleation process during the crystallization of triangular nanoplatelets in water at the single-particle level.

    • Yilong Han

  • Article |

    Doping through spontaneous electron transfer between donor and acceptor polymers is obtained by selecting organic semiconductors with suitable electron affinity and ionization energy, achieving high conductivity in blends and bilayer configuration.

    • Kai Xu
    • , Hengda Sun
    • , Tero-Petri Ruoko
    • , Gang Wang
    • , Renee Kroon
    • , Nagesh B. Kolhe
    • , Yuttapoom Puttisong
    • , Xianjie Liu
    • , Daniele Fazzi
    • , Koki Shibata
    • , Chi-Yuan Yang
    • , Ning Sun
    • , Gustav Persson
    • , Andrew B. Yankovich
    • , Eva Olsson
    • , Hiroyuki Yoshida
    • , Weimin M. Chen
    • , Mats Fahlman
    • , Martijn Kemerink
    • , Samson A. Jenekhe
    • , Christian Müller
    • , Magnus Berggren
    •  & Simone Fabiano

  • News & Views |

    A monolayer topological insulator is magnetized by proximity to a layered antiferromagnetic insulator.

    • Cui-Zu Chang

  • News & Views |

    Skyrmions emerging from complex order offer superior stability and functionality for data processing and storage, but creating such objects is intrinsically difficult. Homochiral electric and antiferromagnetic structures at the domain walls of a room-temperature multiferroic are now observed.

    • Enrico Schierle

  • Article |

    Scanning atomic electron tomography is demonstrated to determine the 3D atomic positions and defects of Re-doped MoS2 monolayers and other 2D materials, providing picometre precision atomic coordinates that can be used as direct input to DFT to reveal more accurate electronic band structures of these systems.

    • Xuezeng Tian
    • , Dennis S. Kim
    • , Shize Yang
    • , Christopher J. Ciccarino
    • , Yongji Gong
    • , Yongsoo Yang
    • , Yao Yang
    • , Blake Duschatko
    • , Yakun Yuan
    • , Pulickel M. Ajayan
    • , Juan Carlos Idrobo
    • , Prineha Narang
    •  & Jianwei Miao

  • News & Views |

    Two initially neutral conjugated semiconducting polymers are found to transfer electrons when put in contact in the solid state, leading to mutual electrical doping.

    • Bernard Kippelen

  • Article |

    Fast oxide ion and proton conductors at intermediate temperature are required to improve the performance of ceramic fuel cells. An undoped hexagonal perovskite Ba7Nb4MoO20 electrolyte with high proton and oxide ion conductivity (4.0 mS cm−1) at 510 °C is now reported.

    • Sacha Fop
    • , Kirstie S. McCombie
    • , Eve J. Wildman
    • , Jan M. S. Skakle
    • , John T. S. Irvine
    • , Paul A. Connor
    • , Cristian Savaniu
    • , Clemens Ritter
    •  & Abbie C. Mclaughlin

  • Article |

    The progressive stiffening of the solid–solid contacts that freeze dense colloidal suspensions are shown to cause the macroscopic ageing of such materials.

    • Francesco Bonacci
    • , Xavier Chateau
    • , Eric M. Furst
    • , Jennifer Fusier
    • , Julie Goyon
    •  & Anaël Lemaître

  • News & Views |

    Through engineering of oxygen stacking and cation–cation interactions, a methodology to design high-energy and long-cycle-life lithium-rich battery materials is proposed.

    • Naoaki Yabuuchi