Takeshi Ishizaki¹ & Shingo Ameshima¹ Shigeru Matsukawa²: reply--Bruce D. Hammock³


 
p27 expression and gastric carcinoma  p 593
Masaki Mori¹, Koshi Mimori¹, Takeshi Shiraishi¹, Shinji Tanaka¹, Hiroaki Ueo², Keizo Sugimachi³ & Tsuyoshi Akiyoshi¹


 
NEWS

 
Tobacco industry runs scared . . . toward developing countries  p 594



 
Drug company buys US cancer treatment clinics  p 595



 
India backs gene therapy programme  p 595



 
Bold action on health marks Labour's first month in office  p 596



 
UK charities move to keep research fraud at bay  p 597



 
Bid for pan-European allergy programme provokes controversy  p 597



 
Sick at heart  p 598



 
Tuskegee apology  p 598



 
Jail ends Gajdusek saga  p 598



 
Strict rules "could make transplants unworkable"  p 598



 
Numbers game fuels debate on international health priorities  p 599



 
COMMENTARY

 
Cardiovascular disease burden increases, NIH funding decreases  p 600
Jan L. Breslow, President, American Heart Association


 
NEWS & VIEWS

 
Tracing the brain's circuitry with functional imaging  p 602
Scott T. Grafton & Mahlon DeLong



 
A stimulating treatment for emphysema  p 603
James C. Hogg



 
Fighting HIV-1 with IL-16  p 605
Michael Baier & Reinhard Kurth



 
Progress of the smart bomb cancer virus.  p 606
Scott W. Lowe



 
Motors, channels and the sounds of silence  p 608
Karen B. Avraham



 
Cytotrophoblasts: Masters of disguise  p 610
Christopher W. G. Redman



 
Gene therapy: Progress, problems, prospects.  p 612
Helen Blau¹ & Paul Khavari²



 
REVIEW

 
The proto-oncogene Bcl-2 and its role in regulating apoptosis  p 614
Guido Kroemer



 
ARTICLES

 
Detection of bladder cancer recurrence by microsatellite analysis of urine  p 621
Gabriel Steiner¹, Mark P. Schoenberg¹, Jurgen F. Linn¹, Li Mao² & David Sidransky^2,3



 
Flt3 ligand induces tumor regression and antitumor immune responses in vivo  p 625
David H. Lynch¹, Alice Andreasen¹, Eugene Maraskovsky¹, James Whitmore², Robert E. Miller¹ & JoAnn C.L. Schuh³



 
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain  p 632
Galina Selivanova¹, Violetta Iotsova², Ismail Okan¹, Michael Fritsche³, Marika Str�m¹, Bernd Groner³, Roland C. Grafstr�m² & Klas G. Wiman¹



 
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents  p 639
Carla Heise¹, Adam Sampson-Johannes¹, Angelica Williams¹, Frank McCormick, Daniel D. Von Hoff² & David H. Kirn¹



 
Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon  p 646
Senji Shirasawa¹, Anne Marie R. Yunker², Kevin A. Roth², Gary A. Brown¹, Susan Horning¹ & Stanley J. Korsmeyer¹



 
Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization  p 651
Michael D. Lubeck¹, Robert Natuk¹, Maria Myagkikh², Narender Kalyan¹, Kristine Aldrich², Faruk Sinangil³, Shabnam Alipanah², Shri C.S. Murthy¹, Pranab K. Chanda¹, Stephen M. Nigida, Jr.⁴, Phillip D. Markham⁵, Susan Zolla-Pazner⁶, Kathy Steimer³, Mark Wade¹, Marvin S. Reitz, Jr.², Larry O. Arthur⁴, Satoshi Mizutani¹, Alan Davis¹, Paul P. Hung¹, Robert C. Gallo², Jorg Eichberg¹ & Marjorie Robert-Guroff²



 
Human CD4⁺ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: Inhibition of mRNA expression  p 659
Paul Zhou¹, Simoy Goldstein², Krishnakumar Devadas¹, Deepanker Tewari¹, & Abner Louis Notkins¹



 
Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptase  p 665
Peter M. Grob¹, Yunzhen Cao², Elizabeth Muchmore³, David D. Ho², Steve Norris⁴, Joseph W. Pav⁴, Cheng-Kon Shih¹, & Julian Adams



 
Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms  p 671
Karen D. Davis¹, Ethan Taub¹, Sylvain Houle², Anthony E. Lang³, Jonathan O. Dostrovsky⁴, Ronald R. Tasker¹ & Andres M. Lozano¹



 
Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats  p 675
Gloria De Carlo Massaro & Donald Massaro



 
Monocyte deactivation in septic patients: Restoration by IFN-* treatment  p 678
Wolf-Dietrich D�cke¹, Felix Randow¹, Uta Syrbe¹, Dietmar Krausch², Khusru Asadullah¹, Petra Reinke³, Hans-Dieter Volk¹, Wolfgang Kox²



 
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors  p 682
Ignacio Melero, Walter W. Shuford, Stephanie Ashe Newby, Alejandro Aruffo, Jeffrey A. Ledbetter, Karl Erik Hellstr�m, Robert S. Mittler & Lieping Chen



 
Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo  p 686
Xian-Ping Lu¹, Andrea Fanjul^1?3, Nathalie Picard¹, Michaela Pfahl¹, Deepa Rungta¹, Karen Nared-Hood¹, Bruce Carter³, Javier Piedrafita², Shiping Tang², Eric Fabbrizio² & Magnus Pfahl^1?3



 
BOOK REVIEW

 
The Perfect Baby: A Pragmatic Approach to Genetics  p 691
by Glenn McGee; Reviewed by Bruce C. Trapnell


 
Variation in the Human Genome (Ciba Foundation Symposium)  p 691
edited by Derek Chadwick & Gail Cardew; Reviewed by Richard R. Hudson


 
How to Report Statistics in Medicine: Annotated Guidelines for Authors, Editors, and Reviewers  p 692
>by Thomas A. Lang & Michelle Secic, American College of Physicians; Reviewed by Michael L. Hancock


 
NEW TECHNOLOGY

 
Selectively infective phage (SIP) technology: A novel method for in vivo selection of interacting protein?ligand pairs  p 694
Stefania Spada & Andreas Pl�ckthun


 
On the market  p 696