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April 1996 Volume 2 Number 4 p 485
editorial
Nature Medicine -- an international journal p 363
  
letters to the editor
Histamine, cimetidine and colorectal cancer p 364
Cardiovascular disease risk p 365
Anorexia nervosa -- more than an eating disorder p 366
news
Growth hormone and AIDS-related wasting p 369
Genentech sheds gp120 vaccine p 370
Did you know? p 371
UK lengthens embryo storage time p 372
Israel legalizes surrogate motherhood... p 372.1
...and the British Medical Association supports it p 372.2
Lorne Cancer Conference gains stature and numbers p 373
Shell oils Baylor gene therapy p 373
US law draws a shaky line on indecency in cyberspace p 374
Medical records hit the "intranet" p 375
New HIV drugs approved after some deal-making p 376
Protestors say "non" to HIV drug lottery p 376
WHO issues another gloomy tuberculosis report p 377
Prying open the African drug market p 378
A UK Advisory Council for xenotransplation p 378
Voluntary euthanasia legalized in Australian Territory p 379
Searching for viruses on the Internet p 380
commentary
Tamoxifen: Teaching an old drug new tricks? p 381
David J. Grainger & James C. Metcalfe
Homocysteine and vascular disease p 386
Kilmer S. McCully
news & views
Tumor suppressor genes in the TGF-beta signaling pathway? p 390
Rosa Serra & Harold L. Moses
New pharmaceutical approaches to the treatment of cystic fibrosis p 392
Stephen J. Delaney & Brandon J. Wainwright
Hemochromatosis: The genetic disorder of the twenty-first century p 394
James C. Barton & Luigi F. Bertoli
HIV and HLA: Confusion or complexity? p 395
Adrian V.S. Hill
Calories lost -- another mediator of cancer cachexia? p 397
Gary J. Nabel1 & Carl Grunfeld2
The myth of a male pill p 398
Malcolm Potts
Toward trophic treatment in parkinsonism: A primate step p 400
Lars Olson
Pathogens & strain diversity: Is sex disruptive? p 401
Nelson B. Freimer1, Sally Blower2 & Montgomery Slatkin3
Drug development train gathering steam p 403
Takahiko Ito & W. Stratford May
article
Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection p 405
R.A. Kaslow1, M. Carrington2, R. Apple3, L. Park4, A. Mu�oz4, A.J. Saah4, J.J. Goedert5, C. Winkler2, S.J. O'Brien6, C. Rinaldo7, R. Detels8, W. Blattner5, J. Phair9, H. Erlich3 & D.L. Mann6
Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures p 412
William A. Paxton1, Scott R. Martin1, Doris Tse1, Thomas R. O'Brien2, Joan Skurnick3, Nancy L. VanDevanter4, Nancy Padian5, James F. Braun6, Donald P. Kotler7, Steven M. Wolinsky8 & Richard A. Koup1
Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney p 418
Yoshitaka Isaka1, Douglas K. Brees1, Kazuko Ikegaya1, Yasufumi Kaneda2, Enyu Imai3, Nancy A. Noble1 & Wayne A. Border1
Expression of human beta-hexosaminidase alpha-subunit gene (the gene defect of Tay-Sachs disease) in mouse brains upon engraftment of transduced progenitor cells p 424
H. Daniel Lacorazza1, Jonathan D. Flax2, Evan Y. Snyder2 & Moncef Jendoubi1
The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease p 430
Gerald P. Walsh1, Esterlina V. Tan1, Eduardo C. dela Cruz1, Rodolfo M. Abalos1, Laarni G. Villahermosa1, Leon J. Young1, Roland V. Cellona1, Jerome B. Nazareno2 & Marcus A. Horwitz3
The maintenance of strain structure in populations of recombining infectious agents p 437
Sunetra Gupta1, Martin C.J. Maiden2, Ian M. Feavers2, Sean Nee1, Robert M. May1 & Roy M. Anderson1
Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion p 443
Charles A. Mecenas, Dino A. Giussani, James R. Owiny, Susan L. Jenkins, Wen X. Wu, M. Barbera O.M. Honnebier, Charles J. Lockwood, Linda Kong, Seth Guller & Peter W. Nathanielsz
Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia p 449
Eduardo A. Garcia-Zepeda1, Marc E. Rothenberg2, Robert T. Ownbey1, Jocelyn Celestin3, Philip Leder2 & Andrew D. Luster1
Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastasis p 457
Shamgar Ben-Eliyahu1, Gayle G. Page2, Raz Yirmiya3 & Anna N. Taylor4
Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer p 461
Graeme I. Murray1, Margaret E. Duncan2, Pauline O'Neil1, William T. Melvin2 & John E. Fothergill2
Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3 p 463
Patrik Ernfors1, Mao Li Duan2, Wael M. ElShamy1 & Barbara Canlon2
Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations p 467
Marybeth Howard1, Raymond A. Frizzell1 & David M. Bedwell2
Acidification of the male reproductive tract by a proton pumping (H+)-ATPase p 470
Sylvie Breton1, Peter J. S. Smith2, Ben Lui1 & Dennis Brown1
Phase-contrast X-ray computed tomography for observing biological soft tissues p 473
Atsushi Momose1, Tohoru Takeda2, Yuji Itai2 & Keiichi Hirano3
book review
A New Prescription for Women's Health: Getting the Best Medical Care in a Man's World p 477
by Bernadine Healy
The Magic Bullet p 478
by Harry Stein
Technology in the Hospital: Transforming Patient Care in the Early Twentieth Century p 479
by Joel D. Howell
Wrong Medicine: Doctors, Patients, and Futile Treatment p 480
by Lawrence J. Schneiderman and Nancy S. Jecker
new technology
Identification of endothelial cell-surface proteins as targets for diagnosis and treatment of disease p 482
On the Market p 485
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