Volume 21 Issue 8, August 2015

Technical Report

  • Technical Report |

    Intravenous administration of a fluorescently labeled c-Met–binding peptide enables visualization of polyps not detected using white light.

    • Jacobus Burggraaf
    • , Ingrid M C Kamerling
    • , Paul B Gordon
    • , Lenneke Schrier
    • , Marieke L de Kam
    • , Andrea J Kales
    • , Ragnar Bendiksen
    • , Bård Indrevoll
    • , Roger M Bjerke
    • , Siver A Moestue
    • , Siavash Yazdanfar
    • , Alexandra M J Langers
    • , Marit Swaerd-Nordmo
    • , Geir Torheim
    • , Madhuri V Warren
    • , Hans Morreau
    • , Philip W Voorneveld
    • , Tessa Buckle
    • , Fijs W B van Leeuwen
    • , Liv-Ingrid Ødegårdstuen
    • , Grethe T Dalsgaard
    • , Andrew Healey
    •  & James C H Hardwick

Resource

Article

  • Article |

    Preconditioning the niche after lung injury allows better engraftment by fetal lung tissue and repair.

    • Chava Rosen
    • , Elias Shezen
    • , Anna Aronovich
    • , Yael Zlotnikov Klionsky
    • , Yasmin Yaakov
    • , Miri Assayag
    • , Inbal Eti Biton
    • , Orna Tal
    • , Guy Shakhar
    • , Herzel Ben-Hur
    • , David Shneider
    • , Zvi Vaknin
    • , Oscar Sadan
    • , Shmuel Evron
    • , Enrique Freud
    • , David Shoseyov
    • , Michael Wilschanski
    • , Neville Berkman
    • , Willem E Fibbe
    • , David Hagin
    • , Carmit Hillel-Karniel
    • , Irit Milman Krentsis
    • , Esther Bachar-Lustig
    •  & Yair Reisner
  • Article |

    AIM2 suppresses colon tumorigenesis, independently of the inflammasome and IL-1β, by interacting with DNA-PK and inhibiting Akt activation.

    • Justin E Wilson
    • , Alex S Petrucelli
    • , Liang Chen
    • , A Alicia Koblansky
    • , Agnieszka D Truax
    • , Yoshitaka Oyama
    • , Arlin B Rogers
    • , W June Brickey
    • , Yuli Wang
    • , Monika Schneider
    • , Marcus Mühlbauer
    • , Wei-Chun Chou
    • , Brianne R Barker
    • , Christian Jobin
    • , Nancy L Allbritton
    • , Dale A Ramsden
    • , Beckley K Davis
    •  & Jenny P Y Ting
  • Article |

    Carl June and colleagues report the results of a phase I/II trial of adoptively transferred engineered T cells in patients with advanced multiple myeloma.

    • Aaron P Rapoport
    • , Edward A Stadtmauer
    • , Gwendolyn K Binder-Scholl
    • , Olga Goloubeva
    • , Dan T Vogl
    • , Simon F Lacey
    • , Ashraf Z Badros
    • , Alfred Garfall
    • , Brendan Weiss
    • , Jeffrey Finklestein
    • , Irina Kulikovskaya
    • , Sanjoy K Sinha
    • , Shari Kronsberg
    • , Minnal Gupta
    • , Sarah Bond
    • , Luca Melchiori
    • , Joanna E Brewer
    • , Alan D Bennett
    • , Andrew B Gerry
    • , Nicholas J Pumphrey
    • , Daniel Williams
    • , Helen K Tayton- Martin
    • , Lilliam Ribeiro
    • , Tom Holdich
    • , Saul Yanovich
    • , Nancy Hardy
    • , Jean Yared
    • , Naseem Kerr
    • , Sunita Philip
    • , Sandra Westphal
    • , Don L Siegel
    • , Bruce L Levine
    • , Bent K Jakobsen
    • , Michael Kalos
    •  & Carl H June
  • Article |

    Neutrophils infiltrate the CNS and promote Alzheimer's disease–like pathology and memory loss.

    • Elena Zenaro
    • , Enrica Pietronigro
    • , Vittorina Della Bianca
    • , Gennj Piacentino
    • , Laura Marongiu
    • , Simona Budui
    • , Ermanna Turano
    • , Barbara Rossi
    • , Stefano Angiari
    • , Silvia Dusi
    • , Alessio Montresor
    • , Tommaso Carlucci
    • , Sara Nanì
    • , Gabriele Tosadori
    • , Lucia Calciano
    • , Daniele Catalucci
    • , Giorgio Berton
    • , Bruno Bonetti
    •  & Gabriela Constantin
  • Article |

    The gut and oral microbiomes are altered in individuals with rheumatoid arthritis, and these changes can be used to stratify individuals for diagnostic and prognostic purposes.

    • Xuan Zhang
    • , Dongya Zhang
    • , Huijue Jia
    • , Qiang Feng
    • , Donghui Wang
    • , Di Liang
    • , Xiangni Wu
    • , Junhua Li
    • , Longqing Tang
    • , Yin Li
    • , Zhou Lan
    • , Bing Chen
    • , Yanli Li
    • , Huanzi Zhong
    • , Hailiang Xie
    • , Zhuye Jie
    • , Weineng Chen
    • , Shanmei Tang
    • , Xiaoqiang Xu
    • , Xiaokai Wang
    • , Xianghang Cai
    • , Sheng Liu
    • , Yan Xia
    • , Jiyang Li
    • , Xingye Qiao
    • , Jumana Yousuf Al-Aama
    • , Hua Chen
    • , Li Wang
    • , Qing-jun Wu
    • , Fengchun Zhang
    • , Wenjie Zheng
    • , Yongzhe Li
    • , Mingrong Zhang
    • , Guangwen Luo
    • , Wenbin Xue
    • , Liang Xiao
    • , Jun Li
    • , Wanting Chen
    • , Xun Xu
    • , Ye Yin
    • , Huanming Yang
    • , Jian Wang
    • , Karsten Kristiansen
    • , Liang Liu
    • , Ting Li
    • , Qingchun Huang
    • , Yingrui Li
    •  & Jun Wang

Letter

  • Letter |

    Clinical testing of BCR inhibition on DLBCL reveals determinants of response.

    • Wyndham H Wilson
    • , Ryan M Young
    • , Roland Schmitz
    • , Yandan Yang
    • , Stefania Pittaluga
    • , George Wright
    • , Chih-Jian Lih
    • , P Mickey Williams
    • , Arthur L Shaffer
    • , John Gerecitano
    • , Sven de Vos
    • , Andre Goy
    • , Vaishalee P Kenkre
    • , Paul M Barr
    • , Kristie A Blum
    • , Andrei Shustov
    • , Ranjana Advani
    • , Nathan H Fowler
    • , Julie M Vose
    • , Rebecca L Elstrom
    • , Thomas M Habermann
    • , Jacqueline C Barrientos
    • , Jesse McGreivy
    • , Maria Fardis
    • , Betty Y Chang
    • , Fong Clow
    • , Brian Munneke
    • , Davina Moussa
    • , Darrin M Beaupre
    •  & Louis M Staudt
  • Letter |

    Circulating β2-microglobulin, a component of MHC I, increases with age, promoting age-related cognitive decline and decreased neurogenesis.

    • Lucas K Smith
    • , Yingbo He
    • , Jeong-Soo Park
    • , Gregor Bieri
    • , Cedric E Snethlage
    • , Karin Lin
    • , Geraldine Gontier
    • , Rafael Wabl
    • , Kristopher E Plambeck
    • , Joe Udeochu
    • , Elizabeth G Wheatley
    • , Jill Bouchard
    • , Alexander Eggel
    • , Ramya Narasimha
    • , Jacqueline L Grant
    • , Jian Luo
    • , Tony Wyss-Coray
    •  & Saul A Villeda
  • Letter |

    In response to signals from afferent TRPV1+ C-fibers, STAT3-dependent upregulation of LCN2 in reactive astrocytes of the spinal dorsal horn amplifies itch signaling in multiple rodent models of atopic and contact dermatitis.

    • Miho Shiratori-Hayashi
    • , Keisuke Koga
    • , Hidetoshi Tozaki-Saitoh
    • , Yuta Kohro
    • , Honami Toyonaga
    • , Chiharu Yamaguchi
    • , Ayumi Hasegawa
    • , Takeshi Nakahara
    • , Junichi Hachisuka
    • , Shizuo Akira
    • , Hideyuki Okano
    • , Masutaka Furue
    • , Kazuhide Inoue
    •  & Makoto Tsuda

Brief Communication

Perspective

  • Perspective |

    In this Perspective, attendees of the Herrenhausen Tumour Heterogeneity meeting discuss the challenges in understanding tumour heterogeneity and propose ways forward for overcoming these hurdles.

    • Ash A Alizadeh
    • , Victoria Aranda
    • , Alberto Bardelli
    • , Cedric Blanpain
    • , Christoph Bock
    • , Christine Borowski
    • , Carlos Caldas
    • , Andrea Califano
    • , Michael Doherty
    • , Markus Elsner
    • , Manel Esteller
    • , Rebecca Fitzgerald
    • , Jan O Korbel
    • , Peter Lichter
    • , Christopher E Mason
    • , Nicholas Navin
    • , Dana Pe'er
    • , Kornelia Polyak
    • , Charles W M Roberts
    • , Lillian Siu
    • , Alexandra Snyder
    • , Hannah Stower
    • , Charles Swanton
    • , Roel G W Verhaak
    • , Jean C Zenklusen
    • , Johannes Zuber
    •  & Jessica Zucman-Rossi

News & Views

  • News & Views |

    Rheumatoid arthritis (RA) is a debilitating autoimmune disorder, the etiology of which is poorly understood. A new study reveals dysbiosis in gut and oral microbiomes of affected individuals, potentially providing a basis for patient stratification and clues to pathophysiological mechanisms of RA onset and progression.

    • Geraint B Rogers
  • News & Views |

    A new study shows that astrocytes are involved in the development of chronic itch in a mouse model. This is dependent on upregulation of lipocalin 2 (LCN2) by the transcription factor STAT-3 and astrogliosis.

    • Dustin Green
    •  & Xinzhong Dong
  • News & Views |

    Engraftment of progenitor cells to effect repair of injured lungs has been a major challenge. A new study combines a conditioning strategy adopted from bone marrow transplantation with a lung injury model to bring this potential therapeutic approach closer to reality.

    • Hans-Willem Snoeck
  • News & Views |

    Aging is a major risk factor for cognitive decline and neurodegenerative diseases. A new study identified β2-microglobulin as a blood-borne factor that detrimentally influences the brain during the aging process.

    • Anthony J Filiano
    •  & Jonathan Kipnis

News Feature

News in Brief

News