Volume 21 Issue 7, July 2015

Volume 21 Issue 7

In this issue, we are proud to feature a collection of articles on inflammatory disease (pp 669–740). The cover image depicts the epithelium that lines the mouse gastrointestinal tract and influences immunity. The cell membrane of small intestinal epithelial cells is visualized in green with the nuclei shown in orange. Paneth cell granules at the base of the crypts are marked in blue. Image courtesy of Mario Noti, Gregory F. Sonnenberg and David Artis. Artwork by Erin Dewalt.

News

News and Views

  • News & Views |

    Two new studies demonstrate that so-called 'liquid biopsies' may reveal important genomic information needed to monitor treatment responses, forecast tumor recurrences, and provide a rationale for novel therapeutic strategies in patients with lung cancer and colon cancer.

    • Catherine B Meador
    •  & Christine M Lovly
  • News & Views |

    Muscle fibrosis after acute injury can be debilitating, but in chronic muscle disease it can be lethal. A new study reveals that shifts in macrophage phenotype in injured or diseased muscle can influence whether connective tissue production by fibro/adipogenic precursors in muscle is beneficial or pathological.

    • James G Tidball
    •  & Michelle Wehling-Henricks
  • News & Views |

    Adipocyte progenitors have the capacity to differentiate into mature brown adipocytes with thermogenic capabilities. Two new studies identify novel markers to help prospectively isolate these and mature adipocytes from human brown fat biopsies.

    • Mariëtte R Boon
    • , Emmani B M Nascimento
    •  & Wouter D van Marken Lichtenbelt

Editorial

  • Editorial |

    Inflammatory disease research is burgeoning. Large data sets are being generated to characterize the human immune response, while detailed mechanistic studies are defining the role of specific cell types and sensors in inflammatory disease. Future efforts are needed to integrate these approaches and guide precision medicine.

Reviews

Articles

  • Article |

    Epigenetic inactivation of a Rab GTPase activating protein confers metastatic properties in melanoma, and it correlates with poor prognosis but better sensitivity to therapy by targeting EGFR signaling.

    • Miguel Vizoso
    • , Humberto J Ferreira
    • , Paula Lopez-Serra
    • , F Javier Carmona
    • , Anna Martínez-Cardús
    • , Maria Romina Girotti
    • , Alberto Villanueva
    • , Sonia Guil
    • , Catia Moutinho
    • , Julia Liz
    • , Anna Portela
    • , Holger Heyn
    • , Sebastian Moran
    • , August Vidal
    • , Maria Martinez-Iniesta
    • , Jose L Manzano
    • , Maria Teresa Fernandez-Figueras
    • , Elena Elez
    • , Eva Muñoz-Couselo
    • , Rafael Botella-Estrada
    • , Alfonso Berrocal
    • , Fredrik Pontén
    • , Joost van den Oord
    • , William M Gallagher
    • , Dennie T Frederick
    • , Keith T Flaherty
    • , Ultan McDermott
    • , Paul Lorigan
    • , Richard Marais
    •  & Manel Esteller
  • Article |

    Whole-genome and targeted sequencing of multiple sections of each of 50 tumors reveals varying degrees of subclonal diversification and genomic heterogeneity.

    • Lucy R Yates
    • , Moritz Gerstung
    • , Stian Knappskog
    • , Christine Desmedt
    • , Gunes Gundem
    • , Peter Van Loo
    • , Turid Aas
    • , Ludmil B Alexandrov
    • , Denis Larsimont
    • , Helen Davies
    • , Yilong Li
    • , Young Seok Ju
    • , Manasa Ramakrishna
    • , Hans Kristian Haugland
    • , Peer Kaare Lilleng
    • , Serena Nik-Zainal
    • , Stuart McLaren
    • , Adam Butler
    • , Sancha Martin
    • , Dominic Glodzik
    • , Andrew Menzies
    • , Keiran Raine
    • , Jonathan Hinton
    • , David Jones
    • , Laura J Mudie
    • , Bing Jiang
    • , Delphine Vincent
    • , April Greene-Colozzi
    • , Pierre-Yves Adnet
    • , Aquila Fatima
    • , Marion Maetens
    • , Michail Ignatiadis
    • , Michael R Stratton
    • , Christos Sotiriou
    • , Andrea L Richardson
    • , Per Eystein Lønning
    • , David C Wedge
    •  & Peter J Campbell
  • Article |

    Human brown and white preadipocyte clones from neck fat depots have been isolated and used to identify genetic biomarkers that predict their thermogenic capacity.

    • Ruidan Xue
    • , Matthew D Lynes
    • , Jonathan M Dreyfuss
    • , Farnaz Shamsi
    • , Tim J Schulz
    • , Hongbin Zhang
    • , Tian Lian Huang
    • , Kristy L Townsend
    • , Yiming Li
    • , Hirokazu Takahashi
    • , Lauren S Weiner
    • , Andrew P White
    • , Maureen S Lynes
    • , Lee L Rubin
    • , Laurie J Goodyear
    • , Aaron M Cypess
    •  & Yu-Hua Tseng
  • Article |

    Ucn3 is released from pancreatic beta cells along with insulin, and it engages a negative feedback loop by promoting somatostatin secretion from delta cells to control further insulin secretion.

    • Talitha van der Meulen
    • , Cynthia J Donaldson
    • , Elena Cáceres
    • , Anna E Hunter
    • , Christopher Cowing-Zitron
    • , Lynley D Pound
    • , Michael W Adams
    • , Andreas Zembrzycki
    • , Kevin L Grove
    •  & Mark O Huising
  • Article |

    BMP9 activates signaling through the BMPR-II receptor in endothelial cells and reverses established disease in three animal models of pulmonary hypertension, thus pointing to a potential new treatment for this disease.

    • Lu Long
    • , Mark L Ormiston
    • , Xudong Yang
    • , Mark Southwood
    • , Stefan Gräf
    • , Rajiv D Machado
    • , Matthias Mueller
    • , Bernd Kinzel
    • , Lai Ming Yung
    • , Janine M Wilkinson
    • , Stephen D Moore
    • , Kylie M Drake
    • , Micheala A Aldred
    • , Paul B Yu
    • , Paul D Upton
    •  & Nicholas W Morrell
  • Article |

    Tgf-β1 contributes to fibrosis during chronic injury by abrogating Tnf-directed apoptosis of fibro/adipogenic progenitor cells during muscle regeneration

    • Dario R Lemos
    • , Farshad Babaeijandaghi
    • , Marcela Low
    • , Chih-Kai Chang
    • , Sunny T Lee
    • , Daniela Fiore
    • , Regan-Heng Zhang
    • , Anuradha Natarajan
    • , Sergei A Nedospasov
    •  & Fabio M V Rossi

Letters

  • Letter |

    By monitoring ctDNA, the authors reveal the dynamic adaption of clonal populations in colorectal cancer patients treated with anti-EGFR therapy, suggesting that therapeutic re-challenge may have some benefit.

    • Giulia Siravegna
    • , Benedetta Mussolin
    • , Michela Buscarino
    • , Giorgio Corti
    • , Andrea Cassingena
    • , Giovanni Crisafulli
    • , Agostino Ponzetti
    • , Chiara Cremolini
    • , Alessio Amatu
    • , Calogero Lauricella
    • , Simona Lamba
    • , Sebastijan Hobor
    • , Antonio Avallone
    • , Emanuele Valtorta
    • , Giuseppe Rospo
    • , Enzo Medico
    • , Valentina Motta
    • , Carlotta Antoniotti
    • , Fabiana Tatangelo
    • , Beatriz Bellosillo
    • , Silvio Veronese
    • , Alfredo Budillon
    • , Clara Montagut
    • , Patrizia Racca
    • , Silvia Marsoni
    • , Alfredo Falcone
    • , Ryan B Corcoran
    • , Federica Di Nicolantonio
    • , Fotios Loupakis
    • , Salvatore Siena
    • , Andrea Sartore-Bianchi
    •  & Alberto Bardelli
  • Letter |

    The introduction of α-synuclein into mouse models of Alzheimer's disease, either by intracerebral injection or transgenic overexpression, is found to inhibit the formation of hippocampal amyloid-β plaques.

    • Teresa Bachhuber
    • , Natalie Katzmarski
    • , Joanna F McCarter
    • , Desiree Loreth
    • , Sabina Tahirovic
    • , Frits Kamp
    • , Claudia Abou-Ajram
    • , Brigitte Nuscher
    • , Alberto Serrano-Pozo
    • , Alexandra Müller
    • , Marco Prinz
    • , Harald Steiner
    • , Bradley T Hyman
    • , Christian Haass
    •  & Melanie Meyer-Luehmann
  • Letter |

    Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.

    • Jing Wang
    • , Chongxiu Sun
    • , Norbert Gerdes
    • , Conglin Liu
    • , Mengyang Liao
    • , Jian Liu
    • , Michael A Shi
    • , Aina He
    • , Yi Zhou
    • , Galina K Sukhova
    • , Huimei Chen
    • , Xian Wu Cheng
    • , Masafumi Kuzuya
    • , Toyoaki Murohara
    • , Jie Zhang
    • , Xiang Cheng
    • , Mengmeng Jiang
    • , Gary E Shull
    • , Shaunessy Rogers
    • , Chao-Ling Yang
    • , Qiang Ke
    • , Sabina Jelen
    • , René Bindels
    • , David H Ellison
    • , Petr Jarolim
    • , Peter Libby
    •  & Guo-Ping Shi

Errata

  • Erratum |

    • Catherine S Grasso
    • , Yujie Tang
    • , Nathalene Truffaux
    • , Noah E Berlow
    • , Lining Liu
    • , Marie-Anne Debily
    • , Michael J Quist
    • , Lara E Davis
    • , Elaine C Huang
    • , Pamelyn J Woo
    • , Anitha Ponnuswami
    • , Spenser Chen
    • , Tessa B Johung
    • , Wenchao Sun
    • , Mari Kogiso
    • , Yuchen Du
    • , Lin Qi
    • , Yulun Huang
    • , Marianne Hütt-Cabezas
    • , Katherine E Warren
    • , Ludivine Le Dret
    • , Paul S Meltzer
    • , Hua Mao
    • , Martha Quezado
    • , Dannis G van Vuurden
    • , Jinu Abraham
    • , Maryam Fouladi
    • , Matthew N Svalina
    • , Nicholas Wang
    • , Cynthia Hawkins
    • , Javad Nazarian
    • , Marta M Alonso
    • , Eric H Raabe
    • , Esther Hulleman
    • , Paul T Spellman
    • , Xiao-Nan Li
    • , Charles Keller
    • , Ranadip Pal
    • , Jacques Grill
    •  & Michelle Monje
  • Erratum |

    • Giulia Siravegna
    • , Benedetta Mussolin
    • , Michela Buscarino
    • , Giorgio Corti
    • , Andrea Cassingena
    • , Giovanni Crisafulli
    • , Agostino Ponzetti
    • , Chiara Cremolini
    • , Alessio Amatu
    • , Calogero Lauricella
    • , Simona Lamba
    • , Sebastijan Hobor
    • , Antonio Avallone
    • , Emanuele Valtorta
    • , Giuseppe Rospo
    • , Enzo Medico
    • , Valentina Motta
    • , Carlotta Antoniotti
    • , Fabiana Tatangelo
    • , Beatriz Bellosillo
    • , Silvio Veronese
    • , Alfredo Budillon
    • , Clara Montagut
    • , Patrizia Racca
    • , Silvia Marsoni
    • , Alfredo Falcone
    • , Ryan B Corcoran
    • , Federica Di Nicolantonio
    • , Fotios Loupakis
    • , Salvatore Siena
    • , Andrea Sartore-Bianchi
    •  & Alberto Bardelli

Focus

  • Focus |

    Inflammatory Disease

    There is an emerging understanding of how the disruption of immune homeostasis may lead to the development of chronic inflammatory diseases. This series of articles highlights new data that point toward the influence of environmental factors and addresses recent advances in our knowledge of the cell types and signaling pathways involved in inflammatory disease onset and progression.