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Volume 21 Issue 2, February 2015

Hundreds of susceptibility loci have previously been associated with autism spectrum disorder (ASD) suggesting the disease is genetically heterogeneous. In this issue, Stephen Scherer and colleagues report a whole-genome sequencing study of 85 quartet families (parents and two ASD-affected siblings). The cover image, courtesy of Linden Gledhill and Autism Speaks, depicts the growing face of a liquid crystal formed from an evaporating aqueous solution of DNA (specifically, the 14 base pair double stranded DNA palindrome fragment 5’-ACGCGAATTCGCGT-3’). The blue color is due to birefringence imaged using cross-polarized light microscopy (magnification, x100).

Editorial

  • With the completion of The Cancer Genome Atlas, it is time to evaluate its impact and mine its data to gain a better understanding of cancer biology and therapy.

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News & Views

  • A study of SIV-infected rhesus macaques suggests that T follicular helper (TFH) cells, a specialized CD4+ T cell subset within the B cell follicles, are a sanctuary for SIV that is largely inaccessible to CD8+ T cells. These findings may open new avenues for research aimed at eradicating HIV.

    • Hendrik Streeck
    News & Views
  • Obesity is a major risk factor for chronic disease. A new study in mice reveals that lowering levels of the signaling molecule serotonin outside of the brain reduces obesity and its complications by increasing brown adipose tissue (BAT) energy expenditure.

    • Andrew L Carey
    • Bronwyn A Kingwell
    News & Views
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Between Bedside and Bench

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Letter

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