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Bioengineered kidney makes urine

Bioengineered kidney makes urine

For the first time, scientists have created lab-grown kidneys in rats that produce urine after transplantation. The work, published in the May 2013 issue of Nature Medicine, could pave the way for producing organs on demand to treat end-stage renal failure in people.

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Regeneration and experimental orthotopic transplantation of a bioengineered kidney

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A view down the esophagus

Developing world diagnostic

Researchers have developed a pill-sized device that provides a three-dimensional image of the esophageal wall. The findings, reported in the February 2013 issue of Nature Medicine, could help doctors screen people for Barrett's esophagus, a disorder caused by chronic exposure to stomach acid.

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Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

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Stem cells put women's reproduction on fertile ground

Developing world diagnostic

Human ovaries contain stem cells with the potential of forming new eggs during a woman's reproductive years. The findings, reported in the March 2012 issue of Nature Medicine, could lead to new therapies that extend female fertility into late middle age and beyond.

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Stem cells put women's reproduction on fertile ground

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Developing world diagnostic

Developing world diagnostic

A credit card-sized device can accurately and cheaply diagnose infectious diseases in the developing world, researchers report in the August 2011 issue of Nature Medicine. In the following video, the study authors describe how the device performed in preliminary field testing in Rwanda.

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Microfluidics-based diagnostics of infectious diseases in the developing world

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Watch this Genspace

Watch this GenSpace

A small group of garage biotechnologists has opened the world's first community laboratory. For just $100 per month, anyone can join Genspace, located in the heart of downtown Brooklyn, New York. In the following video and commentary, the Genspace founders explain how the do-it-yourself biology lab works.

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Engage with, don't fear, community labs

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Hope seen in blocking Parkinson's protein

Hope seen in blocking Parkinson's protein

Blocking a protein called LRRK2 can prevent some of the symptoms of Parkinson's disease in a mouse model of the disease, researchers reported online today in Nature Medicine. In the following video, several New York-based scientists describe how these animal models of Parkinson's are helping researchers discover new drugs that inhibit aberrant LRRK2 activity and could perhaps ultimately treat people suffering from the neurodegenerative disease.

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Abstract | Full text | PDF | Supplementary Information



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Getting under the skin

Getting under the skin

In an effort to better understand skin disorders, researchers have discovered a noninvasive method for silencing genes in the surface epithelia of mouse embryos. This approach, which relies on RNA interference, can now be used to dissect the genetic interactions involved in cancer and other skin diseases, a team led by Rockefeller University's Elaine Fuchs reports in the July issue of Nature Medicine.

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Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos

Abstract | Full text | PDF | Supplementary Information



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New mouse model of OCD

New mouse model of OCD

Scientists have bred an unusually anxious, compulsively overgrooming mouse by knocking out a single gene called Slitrk5. These genetically altered mice, which behave much like people with obsessive compulsive disorder (OCD), could help researchers better understand and treat the debilitating disorder.

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Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice

Abstract | Full text | PDF | Supplementary Information



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The stethoscope in your iPhone

New mouse model of OCD

You might not realize it, but if you have an iPhone, you also have a stethoscope and a CPR trainer within reach. Those are just two of the more than 2,000 medical applications available on the iPhone — and with Apple's iPad launching this Saturday, you can expect plenty more apps to soon help doctors and researchers alike.

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Marker for MS may lead to treatment options

Marker for MS may lead to treatment options

A new blood test seems able to parse whether beta-interferon — the major treatment for multiple sclerosis (MS) — will work for MS patients even before therapy begins. Reporting in the April issue of Nature Medicine, a team led by Larry Steinman, a neurologist at Stanford University, found that the efficacy of the $25,000 per year drug depends on what immune cell type is involved in the disease.

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T helper type 1 and 17 cells determine efficacy of interferon-Β in multiple sclerosis and experimental encephalomyelitis

Abstract | Full text | PDF | Supplementary Information



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Gut insights into boosting bone

Gut insights into boosting bone

Blocking the synthesis of the neurotransmitter serotonin in the gut increased bone mass in mice, researchers report online today in Nature Medicine. The finding could have implications for treating osteoporosis in people. Watch this video to find out how.

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Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

Abstract | Full text | PDF | Supplementary Information


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