Top 10
The top ten charts the articles that have been downloaded most often, in PDF format, from the Nature Medicine website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.
Top of pageArticle
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
Volker Teichgräber, Martina Ulrich, Nicole Endlich, Joachim Riethmüller, Barbara Wilker, Cheyla Conceição De Oliveira–Munding, Anna M van Heeckeren, Mark L Barr, Gabriele von Kürthy, Kurt W Schmid, Michael Weller, Burkhard Tümmler, Florian Lang, Heike Grassme, Gerd Döring & Erich Gulbins
doi:10.1038/nm1748
Abstract - Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis | Full Text - Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis | PDF (649 KB) - Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis | Supplementary information - Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
See also: News and Views by Pier
Letter
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
Christopher A Jones, Nyall R London, Haoyu Chen, Kye Won Park, Dominique Sauvaget, Rebecca A Stockton, Joshua D Wythe, Wonhee Suh, Frederic Larrieu-Lahargue, Yoh-suke Mukouyama, Per Lindblom, Pankaj Seth, Antonio Frias, Naoyuki Nishiya, Mark H Ginsberg, Holger Gerhardt, Kang Zhang & Dean Y Li
doi:10.1038/nm1742
Abstract - Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability | Full Text - Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability | PDF (682 KB) - Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability | Supplementary information - Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
See also: News and Views by Acevedo et al.
Article
Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins
Christine Cirl, Andreas Wieser, Manisha Yadav, Susanne Duerr, Sören Schubert, Hans Fischer, Dominik Stappert, Nina Wantia, Nuria Rodriguez, Hermann Wagner, Catharina Svanborg & Thomas Miethke
doi:10.1038/nm1734
Abstract - Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins | Full Text - Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins | PDF (431 KB) - Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins | Supplementary information - Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins
See also: News and Views by O'Neill
News and Views
Bacteria fight back against Toll-like receptors
Luke A J O'Neill
doi:10.1038/nm0408-370
Abstract - | Full Text - Bacteria fight back against Toll-like receptors | PDF (565 KB) - Bacteria fight back against Toll-like receptors
See also: Article by Cirl et al.
Technical Report
Simultaneous PET-MRI: a new approach for functional and morphological imaging
Martin S Judenhofer, Hans F Wehrl, Danny F Newport, Ciprian Catana, Stefan B Siegel, Markus Becker, Axel Thielscher, Manfred Kneilling, Matthias P Lichy, Martin Eichner, Karin Klingel, Gerald Reischl, Stefan Widmaier, Martin Röcken, Robert E Nutt, Hans-Jürgen Machulla, Kamil Uludag, Simon R Cherry, Claus D Claussen & Bernd J Pichler
doi:10.1038/nm1700
Abstract - Simultaneous PET-MRI: a new approach for functional and morphological imaging | Full Text - Simultaneous PET-MRI: a new approach for functional and morphological imaging | PDF (461 KB) - Simultaneous PET-MRI: a new approach for functional and morphological imaging | Supplementary information - Simultaneous PET-MRI: a new approach for functional and morphological imaging
Brief Communication
Therapeutic cloning in individual parkinsonian mice
Viviane Tabar, Mark Tomishima, Georgia Panagiotakos, Sayaka Wakayama, Jayanthi Menon, Bill Chan, Eiji Mizutani, George Al-Shamy, Hiroshi Ohta, Teruhiko Wakayama & Lorenz Studer
doi:10.1038/nm1732
Abstract - Therapeutic cloning in individual parkinsonian mice | Full Text - Therapeutic cloning in individual parkinsonian mice | PDF (198 KB) - Therapeutic cloning in individual parkinsonian mice | Supplementary information - Therapeutic cloning in individual parkinsonian mice
Editorial
A metareview at the NIH
doi:10.1038/nm0408-351
Abstract - | Full Text - A metareview at the NIH | PDF (84 KB) - A metareview at the NIH
News and Views
Robo4 counteracts VEGF signaling
Lisette M Acevedo, Sara M Weis & David A Cheresh
doi:10.1038/nm0408-372
Abstract - | Full Text - Robo4 counteracts VEGF signaling | PDF (213 KB) - Robo4 counteracts VEGF signaling
See also: Letter by Jones et al.
News
Search for potential autism treatments turns to 'trust hormone'
Alisa Opar
doi:10.1038/nm0408-353
Full Text - Search for potential autism treatments turns to 'trust hormone' | PDF (179 KB) - Search for potential autism treatments turns to 'trust hormone'
News
Gut instincts drive next generation of diabetes medications
Genevive Bjorn
doi:10.1038/nm0408-355
Full Text - Gut instincts drive next generation of diabetes medications | PDF (147 KB) - Gut instincts drive next generation of diabetes medications