Latest Research

  • Letter |

    Aptamer-based proteomic analysis of plasma from healthy individuals aged 18–95 years reveals wave-like patterns of protein expression that are associated with age-related diseases and phenotypic traits.

    • Benoit Lehallier
    • , David Gate
    • , Nicholas Schaum
    • , Tibor Nanasi
    • , Song Eun Lee
    • , Hanadie Yousef
    • , Patricia Moran Losada
    • , Daniela Berdnik
    • , Andreas Keller
    • , Joe Verghese
    • , Sanish Sathyan
    • , Claudio Franceschi
    • , Sofiya Milman
    • , Nir Barzilai
    •  & Tony Wyss-Coray
  • Article |

    Herpes simplex virus-1 encephalitis is linked to variants in a small nucleolar RNA, suggesting a new mechanism for antiviral immunity in cortical neurons.

    • Fabien G. Lafaille
    • , Oliver Harschnitz
    • , Yoon Seung Lee
    • , Peng Zhang
    • , Mary L. Hasek
    • , Gaspard Kerner
    • , Yuval Itan
    • , Osefame Ewaleifoh
    • , Franck Rapaport
    • , Thomas M. Carlile
    • , Madalina E. Carter-Timofte
    • , Dominik Paquet
    • , Kerry Dobbs
    • , Bastian Zimmer
    • , Daxing Gao
    • , Maria F. Rojas-Duran
    • , Dylan Kwart
    • , Vimel Rattina
    • , Michael J. Ciancanelli
    • , Jessica L. McAlpine
    • , Lazaro Lorenzo
    • , Soraya Boucherit
    • , Flore Rozenberg
    • , Rabih Halwani
    • , Benoit Henry
    • , Naima Amenzoui
    • , Zobaida Alsum
    • , Laura Marques
    • , Joseph A. Church
    • , Saleh Al-Muhsen
    • , Marc Tardieu
    • , Ahmed Aziz Bousfiha
    • , Søren R. Paludan
    • , Trine Hyrup Mogensen
    • , Lluis Quintana-Murci
    • , Marc Tessier-Lavigne
    • , Gregory A. Smith
    • , Luigi D. Notarangelo
    • , Lorenz Studer
    • , Wendy Gilbert
    • , Laurent Abel
    • , Jean-Laurent Casanova
    •  & Shen-Ying Zhang
  • Perspective |

    Systemic chronic inflammation increases with age and is linked to the development of several diseases, as presented in this Perspective.

    • David Furman
    • , Judith Campisi
    • , Eric Verdin
    • , Pedro Carrera-Bastos
    • , Sasha Targ
    • , Claudio Franceschi
    • , Luigi Ferrucci
    • , Derek W. Gilroy
    • , Alessio Fasano
    • , Gary W. Miller
    • , Andrew H. Miller
    • , Alberto Mantovani
    • , Cornelia M. Weyand
    • , Nir Barzilai
    • , Jorg J. Goronzy
    • , Thomas A. Rando
    • , Rita B. Effros
    • , Alejandro Lucia
    • , Nicole Kleinstreuer
    •  & George M. Slavich
  • Article |

    Prenatal androgen exposure causes transgenerational increases in offspring susceptibility to polycystic ovary syndrome in adulthood.

    • Sanjiv Risal
    • , Yu Pei
    • , Haojiang Lu
    • , Maria Manti
    • , Romina Fornes
    • , Han-Pin Pui
    • , Zhiyi Zhao
    • , Julie Massart
    • , Claes Ohlsson
    • , Eva Lindgren
    • , Nicolas Crisosto
    • , Manuel Maliqueo
    • , Barbara Echiburú
    • , Amanda Ladrón de Guevara
    • , Teresa Sir-Petermann
    • , Henrik Larsson
    • , Mina A. Rosenqvist
    • , Carolyn E. Cesta
    • , Anna Benrick
    • , Qiaolin Deng
    •  & Elisabet Stener-Victorin
  • Article
    | Open Access

    Analysis of fully clinically annotated and sequenced melanoma tumor samples collected before anti-PD1 treatment suggests that determinants of response differ on the basis of previous anti-CTLA4 therapy, and that tumor mutational burden may not be a strong predictor of response across melanoma subtypes.

    • David Liu
    • , Bastian Schilling
    • , Derek Liu
    • , Antje Sucker
    • , Elisabeth Livingstone
    • , Livnat Jerby-Amon
    • , Lisa Zimmer
    • , Ralf Gutzmer
    • , Imke Satzger
    • , Carmen Loquai
    • , Stephan Grabbe
    • , Natalie Vokes
    • , Claire A. Margolis
    • , Jake Conway
    • , Meng Xiao He
    • , Haitham Elmarakeby
    • , Felix Dietlein
    • , Diana Miao
    • , Adam Tracy
    • , Helen Gogas
    • , Simone M. Goldinger
    • , Jochen Utikal
    • , Christian U. Blank
    • , Ricarda Rauschenberg
    • , Dagmar von Bubnoff
    • , Angela Krackhardt
    • , Benjamin Weide
    • , Sebastian Haferkamp
    • , Felix Kiecker
    • , Ben Izar
    • , Levi Garraway
    • , Aviv Regev
    • , Keith Flaherty
    • , Annette Paschen
    • , Eliezer M. Van Allen
    •  & Dirk Schadendorf
  • Article |

    Imaging of muscle fibrosis with a handheld device could potentially serve as a biomarker for disease progression and response to therapy in patients with Duchenne muscular dystrophy.

    • Adrian P. Regensburger
    • , Lina M. Fonteyne
    • , Jörg Jüngert
    • , Alexandra L. Wagner
    • , Teresa Gerhalter
    • , Armin M. Nagel
    • , Rafael Heiss
    • , Florian Flenkenthaler
    • , Matthias Qurashi
    • , Markus F. Neurath
    • , Nikolai Klymiuk
    • , Elisabeth Kemter
    • , Thomas Fröhlich
    • , Michael Uder
    • , Joachim Woelfle
    • , Wolfgang Rascher
    • , Regina Trollmann
    • , Eckhard Wolf
    • , Maximilian J. Waldner
    •  & Ferdinand Knieling
  • Letter |

    Analysis of known viruses in stool samples from young children with high genetic risk for type 1 diabetes shows that sustained enterovirus B (EV-B) infections, rather than independent, short-duration EV-B infections, might be involved in the development of islet autoimmunity, but not type 1 diabetes.

    • Kendra Vehik
    • , Kristian F. Lynch
    • , Matthew C. Wong
    • , Xiangjun Tian
    • , Matthew C. Ross
    • , Richard A. Gibbs
    • , Nadim J. Ajami
    • , Joseph F. Petrosino
    • , Marian Rewers
    • , Jorma Toppari
    • , Anette G. Ziegler
    • , Jin-Xiong She
    • , Ake Lernmark
    • , Beena Akolkar
    • , William A. Hagopian
    • , Desmond A. Schatz
    • , Jeffrey P. Krischer
    • , Heikki Hyöty
    •  & Richard E. Lloyd
  • Letter |

    Large-scale aptamer-based scanning of plasma proteins coupled with machine learning demonstrates proof-of-concept and feasibility of an individualized health check using a single blood sample.

    • Stephen A. Williams
    • , Mika Kivimaki
    • , Claudia Langenberg
    • , Aroon D. Hingorani
    • , J. P. Casas
    • , Claude Bouchard
    • , Christian Jonasson
    • , Mark A. Sarzynski
    • , Martin J. Shipley
    • , Leigh Alexander
    • , Jessica Ash
    • , Tim Bauer
    • , Jessica Chadwick
    • , Gargi Datta
    • , Robert Kirk DeLisle
    • , Yolanda Hagar
    • , Michael Hinterberg
    • , Rachel Ostroff
    • , Sophie Weiss
    • , Peter Ganz
    •  & Nicholas J. Wareham
  • Article |

    A combination of high-resolution imaging and modeling approaches facilitates the study of the mechanisms and clinical progression of non-alcoholic fatty liver disease in humans.

    • Fabián Segovia-Miranda
    • , Hernán Morales-Navarrete
    • , Michael Kücken
    • , Vincent Moser
    • , Sarah Seifert
    • , Urska Repnik
    • , Fabian Rost
    • , Mario Brosch
    • , Alexander Hendricks
    • , Sebastian Hinz
    • , Christoph Röcken
    • , Dieter Lütjohann
    • , Yannis Kalaidzidis
    • , Clemens Schafmayer
    • , Lutz Brusch
    • , Jochen Hampe
    •  & Marino Zerial
  • Article |

    The first BCL-XL-degrading PROTAC achieves safer and more potent antitumor activity than dual BCL-XL and BCL-2 inhibitor navitoclax because of reduced dose-limiting platelet toxicity and high target specificity.

    • Sajid Khan
    • , Xuan Zhang
    • , Dongwen Lv
    • , Qi Zhang
    • , Yonghan He
    • , Peiyi Zhang
    • , Xingui Liu
    • , Dinesh Thummuri
    • , Yaxia Yuan
    • , Janet S. Wiegand
    • , Jing Pei
    • , Weizhou Zhang
    • , Abhisheak Sharma
    • , Christopher R. McCurdy
    • , Vinitha M. Kuruvilla
    • , Natalia Baran
    • , Adolfo A. Ferrando
    • , Yong-mi Kim
    • , Anna Rogojina
    • , Peter J. Houghton
    • , Guangcun Huang
    • , Robert Hromas
    • , Marina Konopleva
    • , Guangrong Zheng
    •  & Daohong Zhou
  • Article |

    Ultra-sensitive cell-free DNA (cfDNA) sequencing uncovers clonal hematopoiesis as a major source of somatic cfDNA variants in healthy individuals and patients with cancer, and underscores the importance of matched white blood cell DNA sequencing in liquid biopsy procedures.

    • Pedram Razavi
    • , Bob T. Li
    • , David N. Brown
    • , Byoungsok Jung
    • , Earl Hubbell
    • , Ronglai Shen
    • , Wassim Abida
    • , Krishna Juluru
    • , Ino De Bruijn
    • , Chenlu Hou
    • , Oliver Venn
    • , Raymond Lim
    • , Aseem Anand
    • , Tara Maddala
    • , Sante Gnerre
    • , Ravi Vijaya Satya
    • , Qinwen Liu
    • , Ling Shen
    • , Nicholas Eattock
    • , Jeanne Yue
    • , Alexander W. Blocker
    • , Mark Lee
    • , Amy Sehnert
    • , Hui Xu
    • , Megan P. Hall
    • , Angie Santiago-Zayas
    • , William F. Novotny
    • , James M. Isbell
    • , Valerie W. Rusch
    • , George Plitas
    • , Alexandra S. Heerdt
    • , Marc Ladanyi
    • , David M. Hyman
    • , David R. Jones
    • , Monica Morrow
    • , Gregory J. Riely
    • , Howard I. Scher
    • , Charles M. Rudin
    • , Mark E. Robson
    • , Luis A. Diaz Jr.
    • , David B. Solit
    • , Alexander M. Aravanis
    •  & Jorge S. Reis-Filho
  • Letter |

    A new assay combining genotypic and phenotypic information accelerates accurate clinical antibiotic susceptibility testing.

    • Roby P. Bhattacharyya
    • , Nirmalya Bandyopadhyay
    • , Peijun Ma
    • , Sophie S. Son
    • , Jamin Liu
    • , Lorrie L. He
    • , Lidan Wu
    • , Rustem Khafizov
    • , Rich Boykin
    • , Gustavo C. Cerqueira
    • , Alejandro Pironti
    • , Robert F. Rudy
    • , Milesh M. Patel
    • , Rui Yang
    • , Jennifer Skerry
    • , Elizabeth Nazarian
    • , Kimberly A. Musser
    • , Jill Taylor
    • , Virginia M. Pierce
    • , Ashlee M. Earl
    • , Lisa A. Cosimi
    • , Noam Shoresh
    • , Joseph Beechem
    • , Jonathan Livny
    •  & Deborah T. Hung
  • Brief Communication |

    Inhibition of CSF-1R with recurrent activating alterations and other actionable targets identified by genomic sequencing elicits clinical activity in patients with histiocytosis.

    • Benjamin H. Durham
    • , Estibaliz Lopez Rodrigo
    • , Jennifer Picarsic
    • , David Abramson
    • , Veronica Rotemberg
    • , Steven De Munck
    • , Erwin Pannecoucke
    • , Sydney X. Lu
    • , Alessandro Pastore
    • , Akihide Yoshimi
    • , Diana Mandelker
    • , Ozge Ceyhan-Birsoy
    • , Gary A. Ulaner
    • , Michael Walsh
    • , Mariko Yabe
    • , Kseniya Petrova-Drus
    • , Maria E. Arcila
    • , Marc Ladanyi
    • , David B. Solit
    • , Michael F. Berger
    • , David M. Hyman
    • , Mario E. Lacouture
    • , Caroline Erickson
    • , Ruth Saganty
    • , Michelle Ki
    • , Ira J. Dunkel
    • , Vicente Santa-María López
    • , Jaume Mora
    • , Julien Haroche
    • , Jean-Francois Emile
    • , Olivier Decaux
    • , Frederic Geissmann
    • , Savvas N. Savvides
    • , Alexander Drilon
    • , Eli L. Diamond
    •  & Omar Abdel-Wahab
  • Author Correction |

    • Aparna R. Parikh
    • , Ignaty Leshchiner
    • , Liudmila Elagina
    • , Lipika Goyal
    • , Chaya Levovitz
    • , Giulia Siravegna
    • , Dimitri Livitz
    • , Kahn Rhrissorrakrai
    • , Elizabeth E. Martin
    • , Emily E. Van Seventer
    • , Megan Hanna
    • , Kara Slowik
    • , Filippo Utro
    • , Christopher J. Pinto
    • , Alicia Wong
    • , Brian P. Danysh
    • , Ferran Fece de la Cruz
    • , Isobel J. Fetter
    • , Brandon Nadres
    • , Heather A. Shahzade
    • , Jill N. Allen
    • , Lawrence S. Blaszkowsky
    • , Jeffrey W. Clark
    • , Bruce Giantonio
    • , Janet E. Murphy
    • , Ryan D. Nipp
    • , Eric Roeland
    • , David P. Ryan
    • , Colin D. Weekes
    • , Eunice L. Kwak
    • , Jason E. Faris
    • , Jennifer Y. Wo
    • , François Aguet
    • , Ipsita Dey-Guha
    • , Mehlika Hazar-Rethinam
    • , Dora Dias-Santagata
    • , David T. Ting
    • , Andrew X. Zhu
    • , Theodore S. Hong
    • , Todd R. Golub
    • , A. John Iafrate
    • , Viktor A. Adalsteinsson
    • , Alberto Bardelli
    • , Laxmi Parida
    • , Dejan Juric
    • , Gad Getz
    •  & Ryan B. Corcoran
  • Letter |

    Pluripotent stem cells can generate functional lungs when injected into blastocyst-stage mouse embryos, a step toward the goal of growing human lungs in large animals for disease modeling and therapeutic applications.

    • Munemasa Mori
    • , Kazuhiro Furuhashi
    • , Jennifer A. Danielsson
    • , Yuichi Hirata
    • , Miwako Kakiuchi
    • , Chyuan-Sheng Lin
    • , Mayu Ohta
    • , Paul Riccio
    • , Yusuke Takahashi
    • , Xinjing Xu
    • , Charles W. Emala
    • , Chao Lu
    • , Hiromitsu Nakauchi
    •  & Wellington V. Cardoso
  • Letter |

    Epigenetic regulators modulating chromatin accessibility dictate sensitivity to anthracycline-based therapy in early breast cancer and represent potential biomarkers for patient stratification.

    • Jose A. Seoane
    • , Jacob G. Kirkland
    • , Jennifer L. Caswell-Jin
    • , Gerald R. Crabtree
    •  & Christina Curtis
  • Review Article |

    Sex differences in the prevalence, risk factors and symptoms of cardiometabolic disorders are being elucidated and should be taken into account in diagnosis and treatment.

    • Eva Gerdts
    •  & Vera Regitz-Zagrosek
  • Letter |

    The degree of sequence divergence between patient MHC class I alleles influences the response to immune checkpoint blockade therapy independently of tumor mutational burden.

    • Diego Chowell
    • , Chirag Krishna
    • , Federica Pierini
    • , Vladimir Makarov
    • , Naiyer A. Rizvi
    • , Fengshen Kuo
    • , Luc G. T. Morris
    • , Nadeem Riaz
    • , Tobias L. Lenz
    •  & Timothy A. Chan
  • Article |

    Analysis of data from over 400,000 UK Biobank participants shows that eGFR measured by cystatin C, but not serum creatinine, is strongly associated with cardiovascular disease outcomes and mortality.

    • Jennifer S. Lees
    • , Claire E. Welsh
    • , Carlos A. Celis-Morales
    • , Daniel Mackay
    • , James Lewsey
    • , Stuart R. Gray
    • , Donald M. Lyall
    • , John G. Cleland
    • , Jason M. R. Gill
    • , Pardeep S. Jhund
    • , Jill Pell
    • , Naveed Sattar
    • , Paul Welsh
    •  & Patrick B. Mark
  • Article |

    The beneficial effects of exercise on cardiovascular disease are linked to decreased inflammation through crosstalk between adipose tissue and hematopoietic progenitor cells in the bone marrow.

    • Vanessa Frodermann
    • , David Rohde
    • , Gabriel Courties
    • , Nicolas Severe
    • , Maximilian J. Schloss
    • , Hajera Amatullah
    • , Cameron S. McAlpine
    • , Sebastian Cremer
    • , Friedrich F. Hoyer
    • , Fei Ji
    • , Ian D. van Koeverden
    • , Fanny Herisson
    • , Lisa Honold
    • , Gustavo Santos Masson
    • , Shuang Zhang
    • , Jana Grune
    • , Yoshiko Iwamoto
    • , Stephen P. Schmidt
    • , Gregory R. Wojtkiewicz
    • , I-Hsiu Lee
    • , Karin Gustafsson
    • , Gerard Pasterkamp
    • , Saskia C. A. de Jager
    • , Ruslan I. Sadreyev
    • , Jean MacFadyen
    • , Peter Libby
    • , Paul Ridker
    • , David T. Scadden
    • , Kamila Naxerova
    • , Kate L. Jeffrey
    • , Filip K. Swirski
    •  & Matthias Nahrendorf
  • Article |

    A first-in-class engineered receptor decoy that neutralizes CLCF1–CNTFR signaling exhibits antitumor activity in preclinical models of lung adenocarcinoma driven by some mutant KRAS variants and other oncogenic genotypes.

    • Jun W. Kim
    • , Cesar P. Marquez
    • , Kaja Kostyrko
    • , Amanda L. Koehne
    • , Kieren Marini
    • , David R. Simpson
    • , Alex G. Lee
    • , Stanley G. Leung
    • , Leanne C. Sayles
    • , Joseph Shrager
    • , Irene Ferrer
    • , Luis Paz-Ares
    • , Melanie Hayden Gephart
    • , Silvestre Vicent
    • , Jennifer R. Cochran
    •  & E. Alejandro Sweet-Cordero
  • Article |

    Disrupting the normal maturation of the infant gut microbiota induced late-onset sepsis in mice, which could be prevented by administering specific bacteria.

    • Jeffrey R. Singer
    • , Emily G. Blosser
    • , Carlene L. Zindl
    • , Daniel J. Silberger
    • , Sean Conlan
    • , Vincent A. Laufer
    • , Daniel DiToro
    • , Clay Deming
    • , Ranjit Kumar
    • , Casey D. Morrow
    • , Julia A. Segre
    • , Michael J. Gray
    • , David A. Randolph
    •  & Casey T. Weaver
  • Review Article |

    The rise of cardiometabolic diseases in low- and middle-income countries is tied to a multitude of environmental, social and commercial determinants, which are discussed in this Review along with a strategy to counteract those factors.

    • J. Jaime Miranda
    • , Tonatiuh Barrientos-Gutiérrez
    • , Camila Corvalan
    • , Adnan A. Hyder
    • , Maria Lazo-Porras
    • , Tolu Oni
    •  & Jonathan C. K. Wells
  • Letter |

    Large-scale sequencing of coding exons of MRAP2 in 9,418 adults and adolescents identifies loss-of-function mutations that are associated with monogenic obesity, hypertension and hyperglycemia.

    • Morgane Baron
    • , Julie Maillet
    • , Marlène Huyvaert
    • , Aurélie Dechaume
    • , Raphaël Boutry
    • , Hélène Loiselle
    • , Emmanuelle Durand
    • , Bénédicte Toussaint
    • , Emmanuel Vaillant
    • , Julien Philippe
    • , Jérémy Thomas
    • , Amjad Ghulam
    • , Sylvia Franc
    • , Guillaume Charpentier
    • , Jean-Michel Borys
    • , Claire Lévy-Marchal
    • , Maïthé Tauber
    • , Raphaël Scharfmann
    • , Jacques Weill
    • , Cécile Aubert
    • , Julie Kerr-Conte
    • , François Pattou
    • , Ronan Roussel
    • , Beverley Balkau
    • , Michel Marre
    • , Mathilde Boissel
    • , Mehdi Derhourhi
    • , Stefan Gaget
    • , Mickaël Canouil
    • , Philippe Froguel
    •  & Amélie Bonnefond
  • Letter |

    Targeting the adipokine adipsin and its downstream pathway may provide an approach for preservation of beta cell loss in type 2 diabetes.

    • Nicolás Gómez-Banoy
    • , J. Sawalla Guseh
    • , Ge Li
    • , Alfonso Rubio-Navarro
    • , Tong Chen
    • , BreAnne Poirier
    • , Gregory Putzel
    • , Carolina Rosselot
    • , Maria A. Pabón
    • , João Paulo Camporez
    • , Vijeta Bhambhani
    • , Shih-Jen Hwang
    • , Chen Yao
    • , Rachel J. Perry
    • , Sushmita Mukherjee
    • , Martin G. Larson
    • , Daniel Levy
    • , Lukas E. Dow
    • , Gerald I. Shulman
    • , Noah Dephoure
    • , Adolfo Garcia-Ocana
    • , Mingming Hao
    • , Bruce M. Spiegelman
    • , Jennifer E. Ho
    •  & James C. Lo
  • Letter |

    Characterization of the genomic landscape of fetal and placental postpartum tissues shows that chromosomal instability associated with in vitro fertilization (IVF) is not preserved at later stages of prenatal development. Thus rates of de novo numerical aberrations or large structural DNA imbalances are similar between IVF and naturally conceived live-born neonates.

    • Masoud Zamani Esteki
    • , Triin Viltrop
    • , Olga Tšuiko
    • , Airi Tiirats
    • , Mariann Koel
    • , Margit Nõukas
    • , Olga Žilina
    • , Katre Teearu
    • , Heidi Marjonen
    • , Hanna Kahila
    • , Jeroen Meekels
    • , Viveca Söderström-Anttila
    • , Anne-Maria Suikkari
    • , Aila Tiitinen
    • , Reedik Mägi
    • , Sulev Kõks
    • , Nina Kaminen-Ahola
    • , Ants Kurg
    • , Thierry Voet
    • , Joris Robert Vermeesch
    •  & Andres Salumets
  • Brief Communication |

    A unique case from the Colombian cohort of autosomal dominant Alzheimer’s disease is reported in which disease progression is substantially delayed despite unusually high amyloid plaque pathology, possibly related to a rare mutation in APOE3.

    • Joseph F. Arboleda-Velasquez
    • , Francisco Lopera
    • , Michael O’Hare
    • , Santiago Delgado-Tirado
    • , Claudia Marino
    • , Natalia Chmielewska
    • , Kahira L. Saez-Torres
    • , Dhanesh Amarnani
    • , Aaron P. Schultz
    • , Reisa A. Sperling
    • , David Leyton-Cifuentes
    • , Kewei Chen
    • , Ana Baena
    • , David Aguillon
    • , Silvia Rios-Romenets
    • , Margarita Giraldo
    • , Edmarie Guzmán-Vélez
    • , Daniel J. Norton
    • , Enmanuelle Pardilla-Delgado
    • , Arabiye Artola
    • , Justin S. Sanchez
    • , Juliana Acosta-Uribe
    • , Matthew Lalli
    • , Kenneth S. Kosik
    • , Matthew J. Huentelman
    • , Henrik Zetterberg
    • , Kaj Blennow
    • , Rebecca A. Reiman
    • , Ji Luo
    • , Yinghua Chen
    • , Pradeep Thiyyagura
    • , Yi Su
    • , Gyungah R. Jun
    • , Marcus Naymik
    • , Xiaowu Gai
    • , Moiz Bootwalla
    • , Jianling Ji
    • , Lishuang Shen
    • , John B. Miller
    • , Leo A. Kim
    • , Pierre N. Tariot
    • , Keith A. Johnson
    • , Eric M. Reiman
    •  & Yakeel T. Quiroz
  • Letter |

    A single-arm multicenter phase 2 trial demonstrates clinical efficacy of neoadjuvant PD-L1 blockade in patients with resectable muscle-invasive bladder cancer ineligible for cisplatin and examines biomarkers associated with patient outcome.

    • Thomas Powles
    • , Mark Kockx
    • , Alejo Rodriguez-Vida
    • , Ignacio Duran
    • , Simon J. Crabb
    • , Michiel S. Van Der Heijden
    • , Bernadett Szabados
    • , Albert Font Pous
    • , Gwenaelle Gravis
    • , Urbano Anido Herranz
    • , Andrew Protheroe
    • , Alain Ravaud
    • , Denis Maillet
    • , Maria Jose Mendez
    • , Cristina Suarez
    • , Mark Linch
    • , Aaron Prendergast
    • , Pieter-Jan van Dam
    • , Diana Stanoeva
    • , Sofie Daelemans
    • , Sanjeev Mariathasan
    • , Joy S. Tea
    • , Kelly Mousa
    • , Romain Banchereau
    •  & Daniel Castellano
  • Author Correction |

    • Andrew Maltez Thomas
    • , Paolo Manghi
    • , Francesco Asnicar
    • , Edoardo Pasolli
    • , Federica Armanini
    • , Moreno Zolfo
    • , Francesco Beghini
    • , Serena Manara
    • , Nicolai Karcher
    • , Chiara Pozzi
    • , Sara Gandini
    • , Davide Serrano
    • , Sonia Tarallo
    • , Antonio Francavilla
    • , Gaetano Gallo
    • , Mario Trompetto
    • , Giulio Ferrero
    • , Sayaka Mizutani
    • , Hirotsugu Shiroma
    • , Satoshi Shiba
    • , Tatsuhiro Shibata
    • , Shinichi Yachida
    • , Takuji Yamada
    • , Jakob Wirbel
    • , Petra Schrotz-King
    • , Cornelia M. Ulrich
    • , Hermann Brenner
    • , Manimozhiyan Arumugam
    • , Peer Bork
    • , Georg Zeller
    • , Francesca Cordero
    • , Emmanuel Dias-Neto
    • , João Carlos Setubal
    • , Adrian Tett
    • , Barbara Pardini
    • , Maria Rescigno
    • , Levi Waldron
    • , Alessio Naccarati
    •  & Nicola Segata
  • Letter |

    Antibodies in CSF specific for viral peptides implicate enteroviruses in acute flaccid myelitis.

    • Ryan D. Schubert
    • , Isobel A. Hawes
    • , Prashanth S. Ramachandran
    • , Akshaya Ramesh
    • , Emily D. Crawford
    • , John E. Pak
    • , Wesley Wu
    • , Carly K. Cheung
    • , Brian D. O’Donovan
    • , Cristina M. Tato
    • , Amy Lyden
    • , Michelle Tan
    • , Rene Sit
    • , Gavin A. Sowa
    • , Hannah A. Sample
    • , Kelsey C. Zorn
    • , Debarko Banerji
    • , Lillian M. Khan
    • , Riley Bove
    • , Stephen L. Hauser
    • , Amy A. Gelfand
    • , Bethany L. Johnson-Kerner
    • , Kendall Nash
    • , Kalpathy S. Krishnamoorthy
    • , Tanuja Chitnis
    • , Joy Z. Ding
    • , Hugh J. McMillan
    • , Charles Y. Chiu
    • , Benjamin Briggs
    • , Carol A. Glaser
    • , Cynthia Yen
    • , Victoria Chu
    • , Debra A. Wadford
    • , Samuel R. Dominguez
    • , Terry Fei Fan Ng
    • , Rachel L. Marine
    • , Adriana S. Lopez
    • , W. Allan Nix
    • , Ariane Soldatos
    • , Mark P. Gorman
    • , Leslie Benson
    • , Kevin Messacar
    • , Jennifer L. Konopka-Anstadt
    • , M. Steven Oberste
    • , Joseph L. DeRisi
    •  & Michael R. Wilson
  • Letter |

    Neurological phenotypes of PTEN loss are driven by aberrant mTORC2 signaling, and therapeutic inhibition of the mTORC2 component Rictor by antisense oligonucleotides reverses seizures, social interaction deficits and memory impairments in rodents.

    • Chien-Ju Chen
    • , Martina Sgritta
    • , Jacqunae Mays
    • , Hongyi Zhou
    • , Rocco Lucero
    • , Jin Park
    • , I-Ching Wang
    • , Jun Hyoung Park
    • , Benny Abraham Kaipparettu
    • , Loredana Stoica
    • , Paymaan Jafar-Nejad
    • , Frank Rigo
    • , Jeannie Chin
    • , Jeffrey L. Noebels
    •  & Mauro Costa-Mattioli
  • Letter |

    TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

    • Dhruva Biswas
    • , Nicolai J. Birkbak
    • , Rachel Rosenthal
    • , Crispin T. Hiley
    • , Emilia L. Lim
    • , Krisztian Papp
    • , Stefan Boeing
    • , Marcin Krzystanek
    • , Dijana Djureinovic
    • , Linnea La Fleur
    • , Maria Greco
    • , Balázs Döme
    • , János Fillinger
    • , Hans Brunnström
    • , Yin Wu
    • , David A. Moore
    • , Marcin Skrzypski
    • , Christopher Abbosh
    • , Kevin Litchfield
    • , Maise Al Bakir
    • , Thomas B. K. Watkins
    • , Selvaraju Veeriah
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Judit Moldvay
    • , Johan Botling
    • , Arul M. Chinnaiyan
    • , Patrick Micke
    • , Allan Hackshaw
    • , Jiri Bartek
    • , Istvan Csabai
    • , Zoltan Szallasi
    • , Javier Herrero
    • , Nicholas McGranahan
    •  & Charles Swanton
  • Letter |

    Pulmonary venous tumor cells disseminating before tumor resection are heterogeneous, predict relapse and seed future metastasis of lung cancer

    • Francesca Chemi
    • , Dominic G. Rothwell
    • , Nicholas McGranahan
    • , Sakshi Gulati
    • , Chris Abbosh
    • , Simon P. Pearce
    • , Cong Zhou
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Nicolai Birkbak
    • , Jackie Pierce
    • , Chang Sik Kim
    • , Saba Ferdous
    • , Deborah J. Burt
    • , Daniel Slane-Tan
    • , Fabio Gomes
    • , David Moore
    • , Rajesh Shah
    • , Maise Al Bakir
    • , Crispin Hiley
    • , Selvaraju Veeriah
    • , Yvonne Summers
    • , Philip Crosbie
    • , Sophia Ward
    • , Barbara Mesquita
    • , Marek Dynowski
    • , Dhruva Biswas
    • , Jonathan Tugwood
    • , Fiona Blackhall
    • , Crispin Miller
    • , Allan Hackshaw
    • , Ged Brady
    • , Charles Swanton
    •  & Caroline Dive
  • Resource |

    Genetic variants in the germ line modulate DNA methylation in tumors and contribute to the aggressiveness of prostate cancer.

    • Kathleen E. Houlahan
    • , Yu-Jia Shiah
    • , Alexander Gusev
    • , Jiapei Yuan
    • , Musaddeque Ahmed
    • , Anamay Shetty
    • , Susmita G. Ramanand
    • , Cindy Q. Yao
    • , Connor Bell
    • , Edward O’Connor
    • , Vincent Huang
    • , Michael Fraser
    • , Lawrence E. Heisler
    • , Julie Livingstone
    • , Takafumi N. Yamaguchi
    • , Alexandre Rouette
    • , Adrien Foucal
    • , Shadrielle Melijah G. Espiritu
    • , Ankit Sinha
    • , Michelle Sam
    • , Lee Timms
    • , Jeremy Johns
    • , Ada Wong
    • , Alex Murison
    • , Michèle Orain
    • , Valérie Picard
    • , Hélène Hovington
    • , Alain Bergeron
    • , Louis Lacombe
    • , Mathieu Lupien
    • , Yves Fradet
    • , Bernard Têtu
    • , John D. McPherson
    • , Bogdan Pasaniuc
    • , Thomas Kislinger
    • , Melvin L. K. Chua
    • , Mark M. Pomerantz
    • , Theodorus van der Kwast
    • , Matthew L. Freedman
    • , Ram S. Mani
    • , Housheng H. He
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Article |

    A first-in-human, phase 1 dose-escalation trial demonstrates the safety and feasibility of autologous macrophage therapy in adults with liver cirrhosis.

    • Francesca Moroni
    • , Benjamin J. Dwyer
    • , Catriona Graham
    • , Chloe Pass
    • , Laura Bailey
    • , Lisa Ritchie
    • , Donna Mitchell
    • , Alison Glover
    • , Audrey Laurie
    • , Stuart Doig
    • , Emily Hargreaves
    • , Alasdair R. Fraser
    • , Marc L. Turner
    • , John D. M. Campbell
    • , Neil W. A. McGowan
    • , Jacqueline Barry
    • , Joanna K. Moore
    • , Peter C. Hayes
    • , Diana J. Leeming
    • , Mette J. Nielsen
    • , Kishwar Musa
    • , Jonathan A. Fallowfield
    •  & Stuart J. Forbes
  • Article |

    Expansion of human hematopoietic stem cells present in cord blood or bone marrow can be achieved by cell culture in a hydrogel, potentially facilitating clinical applications of hematopoietic cell transplantation.

    • Tao Bai
    • , Jianqiang Li
    • , Andrew Sinclair
    • , Suzan Imren
    • , Fabiola Merriam
    • , Fang Sun
    • , Mary Beth O’Kelly
    • , Cynthia Nourigat
    • , Priyesh Jain
    • , Jeffrey J. Delrow
    • , Ryan S. Basom
    • , Hsiang-Chieh Hung
    • , Peng Zhang
    • , Bowen Li
    • , Shelly Heimfeld
    • , Shaoyi Jiang
    •  & Colleen Delaney
  • Resource |

    Rectal cancer organoids retain the pathological features of matched patient tumors and recapitulate clinical responses to chemoradiation.

    • Karuna Ganesh
    • , Chao Wu
    • , Kevin P. O’Rourke
    • , Bryan C. Szeglin
    • , Youyun Zheng
    • , Charles-Etienne Gabriel Sauvé
    • , Mohammad Adileh
    • , Isaac Wasserman
    • , Michael R. Marco
    • , Amanda S. Kim
    • , Maha Shady
    • , Francisco Sanchez-Vega
    • , Wouter R. Karthaus
    • , Helen H. Won
    • , Seo-Hyun Choi
    • , Raphael Pelossof
    • , Afsar Barlas
    • , Peter Ntiamoah
    • , Emmanouil Pappou
    • , Arthur Elghouayel
    • , James S. Strong
    • , Chin-Tung Chen
    • , Jennifer W. Harris
    • , Martin R. Weiser
    • , Garrett M. Nash
    • , Jose G. Guillem
    • , Iris H. Wei
    • , Richard N. Kolesnick
    • , Harini Veeraraghavan
    • , Eduardo J. Ortiz
    • , Iva Petkovska
    • , Andrea Cercek
    • , Katia O. Manova-Todorova
    • , Leonard B. Saltz
    • , Jessica A. Lavery
    • , Ronald P. DeMatteo
    • , Joan Massagué
    • , Philip B. Paty
    • , Rona Yaeger
    • , Xi Chen
    • , Sujata Patil
    • , Hans Clevers
    • , Michael F. Berger
    • , Scott W. Lowe
    • , Jinru Shia
    • , Paul B. Romesser
    • , Lukas E. Dow
    • , Julio Garcia-Aguilar
    • , Charles L. Sawyers
    •  & J. Joshua Smith
  • Letter |

    A gene therapy vector expressing micro-utrophin provides functional replacement of lost dystrophin, and lacks the adverse immunogenicity associated with direct dystrophin therapy, in rodent and canine models of Duchenne muscular dystrophy.

    • Yafeng Song
    • , Leon Morales
    • , Alock S. Malik
    • , Andrew F. Mead
    • , Christopher D. Greer
    • , Marilyn A. Mitchell
    • , Mihail T. Petrov
    • , Leonard T. Su
    • , Margaret E. Choi
    • , Shira T. Rosenblum
    • , Xiangping Lu
    • , Daniel J. VanBelzen
    • , Ranjith K. Krishnankutty
    • , Frederick J. Balzer
    • , Emanuele Loro
    • , Robert French
    • , Kathleen J. Propert
    • , Shangzhen Zhou
    • , Benjamin W. Kozyak
    • , Peter P. Nghiem
    • , Tejvir S. Khurana
    • , Joe N. Kornegay
    •  & Hansell H. Stedman
  • Article |

    Analysis of monoclonal antibody responses to the Ebola virus vaccine rVSV-ZEBOV in human volunteers.

    • Stefanie A. Ehrhardt
    • , Matthias Zehner
    • , Verena Krähling
    • , Hadas Cohen-Dvashi
    • , Christoph Kreer
    • , Nadav Elad
    • , Henning Gruell
    • , Meryem S. Ercanoglu
    • , Philipp Schommers
    • , Lutz Gieselmann
    • , Ralf Eggeling
    • , Christine Dahlke
    • , Timo Wolf
    • , Nico Pfeifer
    • , Marylyn M. Addo
    • , Ron Diskin
    • , Stephan Becker
    •  & Florian Klein
  • Article |

    A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

    • Kroopa Joshi
    • , Marc Robert de Massy
    • , Mazlina Ismail
    • , James L. Reading
    • , Imran Uddin
    • , Annemarie Woolston
    • , Emine Hatipoglu
    • , Theres Oakes
    • , Rachel Rosenthal
    • , Thomas Peacock
    • , Tahel Ronel
    • , Mahdad Noursadeghi
    • , Virginia Turati
    • , Andrew J. S. Furness
    • , Andrew Georgiou
    • , Yien Ning Sophia Wong
    • , Assma Ben Aissa
    • , Mariana Werner Sunderland
    • , Mariam Jamal-Hanjani
    • , Selvaraju Veeriah
    • , Nicolai J. Birkbak
    • , Gareth A. Wilson
    • , Crispin T. Hiley
    • , Ehsan Ghorani
    • , José Afonso Guerra-Assunção
    • , Javier Herrero
    • , Tariq Enver
    • , Sine R. Hadrup
    • , Allan Hackshaw
    • , Karl S. Peggs
    • , Nicholas McGranahan
    • , Charles Swanton
    • , Sergio A. Quezada
    •  & Benny Chain
  • Letter |

    A luminal unfolding microneedle injector device (LUMI) is engineered as a custom capsule capable of efficient biologic macromolecular drug delivery into the bloodstream via selective deployment within the gastrointestinal tract.

    • Alex Abramson
    • , Ester Caffarel-Salvador
    • , Vance Soares
    • , Daniel Minahan
    • , Ryan Yu Tian
    • , Xiaoya Lu
    • , David Dellal
    • , Yuan Gao
    • , Soyoung Kim
    • , Jacob Wainer
    • , Joy Collins
    • , Siddartha Tamang
    • , Alison Hayward
    • , Tadayuki Yoshitake
    • , Hsiang-Chieh Lee
    • , James Fujimoto
    • , Johannes Fels
    • , Morten Revsgaard Frederiksen
    • , Ulrik Rahbek
    • , Niclas Roxhed
    • , Robert Langer
    •  & Giovanni Traverso