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In a phase Ib trial, neoadjuvant nivolumab or nivolumab/relatlimab prior to chemoradiotherapy were well tolerated and liquid biopsy analyses show that undetectable ctDNA was associated with longer survival.
A large-scale study examined the heterogeneous effects of artificial intelligence (AI) assistance on 140 radiologists across 15 chest X-ray diagnostic tasks and found that conventional experience-based factors, such as years of experience, subspecialty and familiarity with AI tools, fail to reliably predict the impact of AI assistance.
The European Union’s new AI Act focuses on risk without considering benefits, which could hinder the development of new technology while failing to protect the public.
Telehealth provision of medication abortion is safe and effective, but ensuring equitable access is challenging in the USA — and further compounded by an upcoming Supreme Court case.
People with type 2 diabetes who underwent bariatric surgery compared to medical or lifestyle interventions had better long-term outcomes, such as greater diabetes remission and less reliance on medication.
Longitudinal data from the China Cognition and Aging Study map the sequential biomarker changes that begin almost two decades before clinical onset of Alzheimer’s disease.
Chronic pain is common, with more than one in five adult Americans reporting having pain daily or on most days. A multi-ancestry genomic analysis in 598,339 military veterans in the USA identifies 126 genetic variants associated with pain intensity, highlights shared genetic risk with substance use and psychiatric disorders, and reveals enrichment in GABAergic neurons as a key molecular contributor to experiencing pain.
The PRODIGITAL-D trial in adults aged 60+ years from socioeconomically deprived areas of Brazil showed that a 6-week self-help mobile messaging psychosocial intervention was effective in improving depression recovery at 3 months compared to a single message control intervention.
Acute kidney injury affects one in five hospitalized patients and can lead to lasting kidney damage or death. We show that clonal hematopoiesis of indeterminate potential — a common age-related condition caused by blood cell mutations — increases the risk of acute kidney injury in multiple cohorts of human patients and in mouse models.
In an interim analysis of an ongoing phase 1 trial of CAR T cells targeting EGFR and IL13Ra2 in patients with multifocal, recurrent glioblastoma, intrathecal delivery is feasible and well tolerated, with some reductions seen in tumor size.
Analyzing clinical records from a cohort of 3,042 donors in the Netherlands Brain Bank, natural language processing models unveil the symptomatology and potential misdiagnoses of a broad range of neurodegenerative disorders.
Nature Medicine explores the latest translational and clinical research news, with FDA approval of an AI-assisted optical reader to help in the diagnosis of skin cancer.
MEGA is a new CRISPR-based RNA-editing platform with the ability to enhance the fitness of CAR T cells; it may also overcome certain limitations of conventional DNA-targeting CRISPR–Cas9 systems.
After many lean years, important progress has been made in updating the anti-tuberculosis drug armamentarium; a new drug that targets bacterial protein synthesis is one of several that could help transform the treatment of this neglected and deadly disease.
Steatotic liver disease is part of a revised nomenclature to replace the term fatty liver disease, but this should also drive forward innovation in research, diagnostics and treatments.
Sex-stratified genome-wide association studies identify loci showing sex-specific effects on blood pressure, allowing for the development of sex-specific polygenic risk scores for blood pressure traits.
Building on a pre-existing pooling pipeline for the efficient detection of SARS-CoV-2, the results of a large-scale implementation study show the feasibility and benefits of saliva sample pooling to enhance neonatal screening for congenital cytomegalovirus.