Provider: Nature Publishing Group Content: application/x-research-info-systems TY - JOUR AU - Weatherall, D.J. AU - Clegg, J.B. TI - Thalassemia[mdash]a global public health problem JO - Nat. Med. PY - 1996/// VL - 2 SP - 847 EP - 849 M3 - 10.1038/nm0896-847 N1 - 10.1038/nm0896-847 UR - http://dx.doi.org/10.1038/nm0896-847 ER - TY - JOUR AU - Barton, J.C. AU - Bertoli, L.F. TI - Hemochromatosis: the genetic disorder of the twenty-first century JO - Nat. Med. PY - 1996/// VL - 2 SP - 394 EP - 395 M3 - 10.1038/nm0496-394 N1 - 10.1038/nm0496-394 UR - http://dx.doi.org/10.1038/nm0496-394 ER - TY - JOUR AU - Andrews, N.C. TI - Disorders of iron metabolism JO - N. Engl. J. Med. PY - 1999/// VL - 341 SP - 1986 EP - 1995 M3 - 10.1056/NEJM199912233412607 N1 - 10.1056/NEJM199912233412607 UR - http://dx.doi.org/10.1056/NEJM199912233412607 ER - TY - JOUR AU - Ballas, S.K. TI - Iron overload is a determinant of morbidity and mortality in adult patients with sickle cell disease JO - Semin. Hematol. PY - 2001/// VL - 38 SP - 30 EP - 36 M3 - 10.1053/shem.2001.20142 N1 - 10.1053/shem.2001.20142 UR - http://dx.doi.org/10.1053/shem.2001.20142 ER - TY - JOUR AU - Weatherall, D.J. AU - Clegg, J.B. TI - Inherited haemoglobin disorders: an increasing global health problem JO - Bull. World Health Organ. PY - 2001/// VL - 79 SP - 704 EP - 712 ER - TY - JOUR AU - Roy, C.N. AU - Andrews, N.C. TI - Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers JO - Hum. Mol. Genet. PY - 2001/// VL - 10 SP - 2181 EP - 2186 M3 - 10.1093/hmg/10.20.2181 N1 - 10.1093/hmg/10.20.2181 UR - http://dx.doi.org/10.1093/hmg/10.20.2181 ER - TY - JOUR AU - Buja, L.M. AU - Roberts, W.C. TI - Iron in the heart. Etiology and clinical significance JO - Am. J. Med. PY - 1971/// VL - 51 SP - 209 EP - 221 M3 - 10.1016/0002-9343(71)90240-3 N1 - 10.1016/0002-9343(71)90240-3 UR - http://dx.doi.org/10.1016/0002-9343(71)90240-3 ER - TY - JOUR AU - Low, L.C. TI - Growth, puberty and endocrine function in beta-thalassaemia major JO - J. Pediatr. Endocrinol. Metab. PY - 1997/// VL - 10 SP - 175 EP - 184 ER - TY - JOUR AU - Weatherall, D.J. TI - Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias JO - Nat. Rev. Genet. PY - 2001/// VL - 2 SP - 245 EP - 255 M3 - 10.1038/35066048 N1 - 10.1038/35066048 UR - http://dx.doi.org/10.1038/35066048 ER - TY - JOUR AU - Zurlo, M.G. TI - Survival and causes of death in thalassaemia major JO - Lancet PY - 1989/// VL - 2 SP - 27 EP - 30 M3 - 10.1016/S0140-6736(89)90264-X N1 - 10.1016/S0140-6736(89)90264-X UR - http://dx.doi.org/10.1016/S0140-6736(89)90264-X ER - TY - JOUR AU - Olivieri, N.F. TI - Survival in medically treated patients with homozygous beta- thalassemia JO - N. Engl. J. Med. PY - 1994/// VL - 331 SP - 574 EP - 578 M3 - 10.1056/NEJM199409013310903 N1 - 10.1056/NEJM199409013310903 UR - http://dx.doi.org/10.1056/NEJM199409013310903 ER - TY - JOUR AU - Brittenham, G.M. TI - Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major JO - N. Engl. J. Med. PY - 1994/// VL - 331 SP - 567 EP - 573 M3 - 10.1056/NEJM199409013310902 N1 - 10.1056/NEJM199409013310902 UR - http://dx.doi.org/10.1056/NEJM199409013310902 ER - TY - JOUR AU - Niederau, C. TI - Long-term survival in patients with hereditary hemochromatosis JO - Gastroenterology PY - 1996/// VL - 110 SP - 1107 EP - 1119 ER - TY - JOUR AU - Cecchetti, G. TI - Cardiac alterations in 36 consecutive patients with idiopathic haemochromatosis: polygraphic and echocardiographic evaluation JO - Eur. Heart J. PY - 1991/// VL - 12 SP - 224 EP - 230 ER - TY - GEN AU - Muhlestein, J.B. TI - Hemochromatosis: Genetics, Pathophysiology, Diagnosis, and Treatment PY - 2000/// ER - TY - JOUR AU - Palka, P. AU - Macdonald, G. AU - Lange, A. AU - Burstow, D.J. TI - The role of Doppler left ventricular filling indexes and Doppler tissue echocardiography in the assessment of cardiac involvement in hereditary hemochromatosis JO - J. Am. Soc. Echocardiogr. PY - 2002/// VL - 15 SP - 884 EP - 890 M3 - 10.1067/mje.2002.118032 N1 - 10.1067/mje.2002.118032 UR - http://dx.doi.org/10.1067/mje.2002.118032 ER - TY - JOUR AU - Kremastinos, D.T. TI - Left ventricular diastolic Doppler characteristics in beta- thalassemia major JO - Circulation PY - 1993/// VL - 88 SP - 1127 EP - 1135 ER - TY - JOUR AU - Liu, P. AU - Olivieri, N. TI - Iron overload cardiomyopathies: new insights into an old disease JO - Cardiovasc. Drugs Ther. PY - 1994/// VL - 8 SP - 101 EP - 110 ER - TY - JOUR AU - Gharzuddine, W.S. TI - Doppler characterization of left ventricular diastolic function in beta-thalassaemia major. Evidence for an early stage of impaired relaxation JO - Eur. J. Echocardiogr. PY - 2002/// VL - 3 SP - 47 EP - 51 M3 - 10.1053/euje.2001.0114 N1 - 10.1053/euje.2001.0114 UR - http://dx.doi.org/10.1053/euje.2001.0114 ER - TY - JOUR AU - Jensen, C.E. TI - Incidence of endocrine complications and clinical disease severity related to genotype analysis and iron overload in patients with beta-thalassaemia JO - Eur. J. Haematol. PY - 1997/// VL - 59 SP - 76 EP - 81 ER - TY - GEN AU - Strohmeyer, G. AU - Niederau, C. TI - Hemochromatosis: Genetics, Pathophysiology, Diagnosis, and Treatment PY - 2000/// ER - TY - JOUR AU - Niederau, C. TI - Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis JO - N. Engl. J. Med. PY - 1985/// VL - 313 SP - 1256 EP - 1262 ER - TY - JOUR AU - Olivieri, N.F. TI - The beta-thalassemias JO - N. Engl. J. Med. PY - 1999/// VL - 341 SP - 99 EP - 109 M3 - 10.1056/NEJM199907083410207 N1 - 10.1056/NEJM199907083410207 UR - http://dx.doi.org/10.1056/NEJM199907083410207 ER - TY - JOUR AU - Modell, B. AU - Khan, M. AU - Darlison, M. TI - Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register JO - Lancet PY - 2000/// VL - 355 SP - 2051 EP - 2052 M3 - 10.1016/S0140-6736(00)02357-6 N1 - 10.1016/S0140-6736(00)02357-6 UR - http://dx.doi.org/10.1016/S0140-6736(00)02357-6 ER - TY - JOUR AU - Galanello, R. TI - Iron chelation: new therapies JO - Semin. Hematol. PY - 2001/// VL - 38 SP - 73 EP - 76 M3 - 10.1053/shem.2001.20147 N1 - 10.1053/shem.2001.20147 UR - http://dx.doi.org/10.1053/shem.2001.20147 ER - TY - JOUR AU - Chaston, T.B. AU - Richardson, D.R. TI - Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity JO - Am. J. Hematol. PY - 2003/// VL - 73 SP - 200 EP - 210 M3 - 10.1002/ajh.10348 N1 - 10.1002/ajh.10348 UR - http://dx.doi.org/10.1002/ajh.10348 ER - TY - JOUR AU - Link, G. AU - Pinson, A. AU - Hershko, C. TI - Heart cells in culture: a model of myocardial iron overload and chelation JO - J. Lab. Clin. Med. PY - 1985/// VL - 106 SP - 147 EP - 153 ER - TY - JOUR AU - Randell, E.W. AU - Parkes, J.G. AU - Olivieri, N.F. AU - Templeton, D.M. TI - Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron JO - J. Biol. Chem. PY - 1994/// VL - 269 SP - 16046 EP - 16053 ER - TY - JOUR AU - Templeton, D.M. AU - Liu, Y. TI - Genetic regulation of cell function in response to iron overload or chelation JO - Biochim. Biophys. Acta PY - 2003/// VL - 1619 SP - 113 EP - 124 M3 - 10.1016/S0304-4165(02)00497-X N1 - 10.1016/S0304-4165(02)00497-X UR - http://dx.doi.org/10.1016/S0304-4165(02)00497-X ER - TY - JOUR AU - Parkes, J.G. AU - Olivieri, N.F. AU - Templeton, D.M. TI - Characterization of Fe2+ and Fe3+ transport by iron-loaded cardiac myocytes JO - Toxicology PY - 1997/// VL - 117 SP - 141 EP - 151 M3 - 10.1016/S0300-483X(96)03566-4 N1 - 10.1016/S0300-483X(96)03566-4 UR - http://dx.doi.org/10.1016/S0300-483X(96)03566-4 ER - TY - JOUR AU - Gunshin, H. TI - Iron-dependent regulation of the divalent metal ion transporter JO - FEBS Lett. PY - 2001/// VL - 509 SP - 309 EP - 316 M3 - 10.1016/S0014-5793(01)03189-1 N1 - 10.1016/S0014-5793(01)03189-1 UR - http://dx.doi.org/10.1016/S0014-5793(01)03189-1 ER - TY - JOUR AU - Tsushima, R.G. TI - Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload JO - Circ. Res. PY - 1999/// VL - 84 SP - 1302 EP - 1309 ER - TY - JOUR AU - Winegar, B.D. AU - Kelly, R. AU - Lansman, J.B. TI - Block of current through single calcium channels by Fe, Co, and Ni. Location of the transition metal binding site in the pore JO - J. Gen. Physiol. PY - 1991/// VL - 97 SP - 351 EP - 367 M3 - 10.1085/jgp.97.2.351 N1 - 10.1085/jgp.97.2.351 UR - http://dx.doi.org/10.1085/jgp.97.2.351 ER - TY - JOUR AU - Gunshin, H. TI - Cloning and characterization of a mammalian proton-coupled metal-ion transporter JO - Nature PY - 1997/// VL - 388 SP - 482 EP - 488 M3 - 10.1038/41343 N1 - 10.1038/41343 UR - http://dx.doi.org/10.1038/41343 ER - TY - JOUR AU - Muth, J.N. AU - Varadi, G. AU - Schwartz, A. TI - Use of transgenic mice to study voltage-dependent Ca2+ channels JO - Trends Pharmacol. Sci. PY - 2001/// VL - 22 SP - 526 EP - 532 M3 - 10.1016/S0165-6147(00)01797-1 N1 - 10.1016/S0165-6147(00)01797-1 UR - http://dx.doi.org/10.1016/S0165-6147(00)01797-1 ER - TY - JOUR AU - Catterall, W.A. TI - Structure and regulation of voltage-gated Ca2+ channels JO - Annu. Rev. Cell. Dev. Biol. PY - 2000/// VL - 16 SP - 521 EP - 555 M3 - 10.1146/annurev.cellbio.16.1.521 N1 - 10.1146/annurev.cellbio.16.1.521 UR - http://dx.doi.org/10.1146/annurev.cellbio.16.1.521 ER - TY - JOUR AU - Wang, S.Q. AU - Song, L.S. AU - Lakatta, E.G. AU - Cheng, H. TI - Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells JO - Nature PY - 2001/// VL - 410 SP - 592 EP - 596 M3 - 10.1038/35069083 N1 - 10.1038/35069083 UR - http://dx.doi.org/10.1038/35069083 ER - TY - JOUR AU - Peri, R. AU - Triggle, D.J. AU - Singh, S. TI - Regulation of L-type calcium channels in pituitary GH(4)C(1) cells by depolarization JO - J. Biol. Chem. PY - 2001/// VL - 276 SP - 31667 EP - 31673 M3 - 10.1074/jbc.M102613200 N1 - 10.1074/jbc.M102613200 UR - http://dx.doi.org/10.1074/jbc.M102613200 ER - TY - JOUR AU - Ligon, B. AU - Boyd, A.E. AU - Dunlap, K. TI - Class A calcium channel variants in pancreatic islets and their role in insulin secretion JO - J. Biol. Chem. PY - 1998/// VL - 273 SP - 13905 EP - 13911 M3 - 10.1074/jbc.273.22.13905 N1 - 10.1074/jbc.273.22.13905 UR - http://dx.doi.org/10.1074/jbc.273.22.13905 ER - TY - JOUR AU - Kivisto, K.T. AU - Neuvonen, P.J. AU - Tarssanen, L. TI - Pharmacokinetics of verapamil in overdose JO - Hum. Exp. Toxicol. PY - 1997/// VL - 16 SP - 35 EP - 37 ER - TY - JOUR AU - Mikus, G. TI - Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action JO - J. Pharmacol. Exp. Ther. PY - 1990/// VL - 253 SP - 1042 EP - 1048 ER - TY - JOUR AU - Carvalho, M. TI - Amlodipine bioequivalence study: quantification by liquid chromatography coupled to tandem mass spectrometry JO - Biopharm. Drug Dispos. PY - 2001/// VL - 22 SP - 383 EP - 390 M3 - 10.1002/bdd.282 N1 - 10.1002/bdd.282 UR - http://dx.doi.org/10.1002/bdd.282 ER - TY - JOUR AU - Rychkov, G. AU - Brereton, H.M. AU - Harland, M.L. AU - Barritt, G.J. TI - Plasma membrane Ca2+ release-activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells JO - Hepatology PY - 2001/// VL - 33 SP - 938 EP - 947 M3 - 10.1053/jhep.2001.23051 N1 - 10.1053/jhep.2001.23051 UR - http://dx.doi.org/10.1053/jhep.2001.23051 ER - TY - JOUR AU - Link, G. AU - Konijn, A.M. AU - Hershko, C. TI - Cardioprotective effect of alpha-tocopherol, ascorbate, deferoxamine, and deferiprone: mitochondrial function in cultured, iron-loaded heart cells JO - J. Lab. Clin. Med. PY - 1999/// VL - 133 SP - 179 EP - 188 M3 - 10.1016/S0022-2143(99)90011-2 N1 - 10.1016/S0022-2143(99)90011-2 UR - http://dx.doi.org/10.1016/S0022-2143(99)90011-2 ER - TY - JOUR AU - Hershko, C. AU - Link, G. AU - Pinson, A. TI - Modification of iron uptake and lipid peroxidation by hypoxia, ascorbic acid, and alpha-tocopherol in iron-loaded rat myocardial cell cultures JO - J. Lab. Clin. Med. PY - 1987/// VL - 110 SP - 355 EP - 361 ER - TY - JOUR AU - Young, I.S. TI - Antioxidant status and lipid peroxidation in hereditary haemochromatosis JO - Free Radic. Biol. Med. PY - 1994/// VL - 16 SP - 393 EP - 397 M3 - 10.1016/0891-5849(94)90041-8 N1 - 10.1016/0891-5849(94)90041-8 UR - http://dx.doi.org/10.1016/0891-5849(94)90041-8 ER - TY - JOUR AU - Livrea, M.A. TI - Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants JO - Blood PY - 1996/// VL - 88 SP - 3608 EP - 3614 ER - TY - JOUR AU - Fuhr, U. TI - Effects of grapefruit juice and smoking on verapamil concentrations in steady state JO - Eur. J. Clin. Pharmacol. PY - 2002/// VL - 58 SP - 45 EP - 53 M3 - 10.1007/s00228-002-0436-7 N1 - 10.1007/s00228-002-0436-7 UR - http://dx.doi.org/10.1007/s00228-002-0436-7 ER - TY - JOUR AU - Muller, F.B. TI - Once a day verapamil in essential hypertension JO - Br. J. Clin. Pharmacol. PY - 1986/// VL - 21 SP - 143S EP - 147S ER - TY - JOUR AU - Dilger, K. TI - Chronopharmacology of intravenous and oral modified release verapamil JO - Br. J. Clin. Pharmacol. PY - 1999/// VL - 47 SP - 413 EP - 419 M3 - 10.1046/j.1365-2125.1999.00910.x N1 - 10.1046/j.1365-2125.1999.00910.x UR - http://dx.doi.org/10.1046/j.1365-2125.1999.00910.x ER - TY - JOUR AU - Song, L.S. TI - Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel JO - Circ. Res. PY - 2002/// VL - 90 SP - 174 EP - 181 M3 - 10.1161/hh0202.103230 N1 - 10.1161/hh0202.103230 UR - http://dx.doi.org/10.1161/hh0202.103230 ER - TY - JOUR AU - Kremastinos, D.T. AU - Tiniakos, G. AU - Theodorakis, G.N. AU - Katritsis, D.G. AU - Toutouzas, P.K. TI - Myocarditis in beta-thalassemia major. A cause of heart failure JO - Circulation PY - 1995/// VL - 91 SP - 66 EP - 71 ER - TY - JOUR AU - McKie, A.T. TI - An iron-regulated ferric reductase associated with the absorption of dietary iron JO - Science PY - 2001/// VL - 291 SP - 1755 EP - 1759 M3 - 10.1126/science.1057206 N1 - 10.1126/science.1057206 UR - http://dx.doi.org/10.1126/science.1057206 ER - TY - JOUR AU - Andrews, N.C. TI - Metal transporters and disease JO - Curr. Opin. Chem. Biol. PY - 2002/// VL - 6 SP - 181 EP - 186 M3 - 10.1016/S1367-5931(02)00307-1 N1 - 10.1016/S1367-5931(02)00307-1 UR - http://dx.doi.org/10.1016/S1367-5931(02)00307-1 ER - TY - JOUR AU - Ferris, C.D. TI - Haem oxygenase-1 prevents cell death by regulating cellular iron JO - Nat. Cell Biol. PY - 1999/// VL - 1 SP - 152 EP - 157 M3 - 10.1038/11072 N1 - 10.1038/11072 UR - http://dx.doi.org/10.1038/11072 ER - TY - JOUR AU - Esterbauer, H. AU - Schaur, R.J. AU - Zollner, H. TI - Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes JO - Free Radic. Biol. Med. PY - 1991/// VL - 11 SP - 81 EP - 128 M3 - 10.1016/0891-5849(91)90192-6 N1 - 10.1016/0891-5849(91)90192-6 UR - http://dx.doi.org/10.1016/0891-5849(91)90192-6 ER - TY - JOUR AU - Lee, S.H. AU - Oe, T. AU - Blair, I.A. TI - Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins JO - Science PY - 2001/// VL - 292 SP - 2083 EP - 2086 M3 - 10.1126/science.1059501 N1 - 10.1126/science.1059501 UR - http://dx.doi.org/10.1126/science.1059501 ER - TY - JOUR AU - Cohn, R.D. TI - Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex JO - J. Clin. Invest. PY - 2001/// VL - 107 SP - R1 EP - R7 ER - TY - JOUR AU - Abernethy, D.R. AU - Schwartz, J.B. TI - Calcium-antagonist drugs JO - N. Engl. J. Med. PY - 1999/// VL - 341 SP - 1447 EP - 1457 M3 - 10.1056/NEJM199911043411907 N1 - 10.1056/NEJM199911043411907 UR - http://dx.doi.org/10.1056/NEJM199911043411907 ER - TY - JOUR TI - Effect of nifedipine and cerivastatin on coronary endothelial function in patients with coronary artery disease: the ENCORE I Study (Evaluation of Nifedipine and Cerivastatin On Recovery of coronary Endothelial function) JO - Circulation PY - 2003/// VL - 107 SP - 422 EP - 428 ER - TY - JOUR AU - Mason, R.P. AU - Mak, I.T. AU - Trumbore, M.W. AU - Mason, P.E. TI - Antioxidant properties of calcium antagonists related to membrane biophysical interactions JO - Am. J. Cardiol. PY - 1999/// VL - 84 SP - 16L EP - 22L M3 - 10.1016/S0002-9149(99)00360-4 N1 - 10.1016/S0002-9149(99)00360-4 UR - http://dx.doi.org/10.1016/S0002-9149(99)00360-4 ER - TY - JOUR AU - Nawrath, H. AU - Wegener, J.W. TI - Kinetics and state-dependent effects of verapamil on cardiac L-type calcium channels JO - Naunyn Schmiedebergs Arch. Pharmacol. PY - 1997/// VL - 355 SP - 79 EP - 86 ER - TY - JOUR AU - Kass, R.S. AU - Arena, J.P. AU - Chin, S. TI - Cellular electrophysiology of amlodipine: probing the cardiac L-type calcium channel JO - Am. J. Cardiol. PY - 1989/// VL - 64 SP - 35I EP - 41I M3 - 10.1016/0002-9149(89)90958-2 N1 - 10.1016/0002-9149(89)90958-2 UR - http://dx.doi.org/10.1016/0002-9149(89)90958-2 ER - TY - JOUR AU - Luo, X.P. AU - Yazdanpanah, M. AU - Bhooi, N. AU - Lehotay, D.C. TI - Determination of aldehydes and other lipid peroxidation products in biological samples by gas chromatography-mass spectrometry JO - Anal. Biochem. PY - 1995/// VL - 228 SP - 294 EP - 298 M3 - 10.1006/abio.1995.1353 N1 - 10.1006/abio.1995.1353 UR - http://dx.doi.org/10.1006/abio.1995.1353 ER - TY - JOUR AU - Crackower, M.A. TI - Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways JO - Cell PY - 2002/// VL - 110 SP - 737 EP - 749 M3 - 10.1016/S0092-8674(02)00969-8 N1 - 10.1016/S0092-8674(02)00969-8 UR - http://dx.doi.org/10.1016/S0092-8674(02)00969-8 ER -