Laura J. Van't Veer and Britta Weigelt are at The Netherlands Cancer Institute, Molecular Pathology, 121 Plesmanlaan, 1066 cx Amsterdam, The Netherlands. l.vt.veer@nki.nl or b.weigelt@nki.nl
When do cancer cells acquire metastatic identity? Recent reports have indicated that the propensity to metastasize might be hardwired early during tumor development. Now it seems that breast cancer cells might acquire a gene signature early in tumorigenesis that predicts the site of metastasis.
