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Nature Medicine 9, 820 - 822 (2003)
doi:10.1038/nm0703-820
Dengue immune response: low affinity, high febrility
Raymond M Welsh1 & Alan L Rothman1
- The authors are in the Departments of Pathology and Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. e-mail: Raymond.Welsh@umassmed.edu
Abstract
Immunity built up after dengue virus infection protects only poorly against reinfection by a virus of a different serotype, and second infections are often even more severe. A new study examines why (pages 921–927).
The immune response to viruses treads a fine line between damage to the host and control of the pathogen. In the face of this delicate balance, partial or incomplete immunity to a pathogen can sometimes be worse than no immunity.
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