Polyglutamine neurodegeneration: minding your Ps and Qs
Henry Paulson
The author is in the Department of Neurology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52245, USA. henry-paulson@uiowa.edu
Expanded glutamine repeats cause brain degeneration associated with protein misfolding and aggregation. Two studies now look beyond the repeat, implicating the phosphatidylinositol-3-kinase (PI-3K)/Akt signaling pathway and 14-3-3 proteins in polyglutamine toxicity.
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