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Advances in angiogenesis are leading to new therapies for ischemic injury and new approaches to treat cancer, blindness and other pathological disorders. On pages 653-725 of this issue, we present eight reviews in a special focus featuring the latest developments in angiogenesis research and its clinical applications. The reviews, and additional editorial content, are free to registered users on our website until 31 July 2003. The cover image depicts a stylized electron micrograph of vessels in the normal rat microvasculature.
From the early days of her graduate career to her forensic work in mass graves and recent research in the turbulent Middle East, Mary-Claire King has never been afraid to make waves. Her greatest accolade, however, is her enduring relationship with the families she has helped.
Herbal supplements such as ephedra and kava kava have increasingly been linked to serious illness and death. So why are they still being sold? Apoorva Mandavilli reports.
Autoimmunity is suspected to contribute to the formation of atherosclerotic plaques. Studies in mice suggest that this response may instead be protective—and that it may be enhanced with a vaccine (pages 736–743).
Vaccines using DNA for priming and recombinant modified vaccinia Ankara virus (MVA) for boosting have shown great promise in preclinical models. Now, this novel protocol appears effective in humans (pages 729–735).
Mutations in the gene that encodes nuclear lamins A and C cause a host of diseases, ranging from dilated cardiomyopathy to lipid disorders. The aging syndrome, Hutchinson-Gilford progeria, is now added to the list.
Is diabetes a disease of the central nervous system? New data point in that direction. Alterations of the levels of long chain fatty acids in the hypothalamus are now shown to influence glucose homeostasis (pages 756–761).
T cells are recruited into the battle against pathogens by interaction with professional antigen-presenting cells (APCs). A new study shows that this recruitment phase is short and terminates when newly activated T cells kill the activating APCs.
Interleukin (IL)-2 can shrink tumors in patients with refractory melanoma and renal cancer, two of the deadliest types of solid tumors, but the use of IL-2 is limited by its high toxicity. A new drug reduces the side effects in mouse models and boosts the tumor-busting capacity of IL-2 (pages 750–755).