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Nature Medicine 9, 503 - 504 (2003)
Published online: 14 April 2003 | doi:10.1038/nm868
Building a better tuberculosis vaccine
Douglas B. Young1
- Centre for Molecular Microbiology and Infection Imperial College London, UK e-mail: d.young@imperial.ac.uk
Abstract
Restoration of genes lost during the original attenuation of the commonly used BCG tuberculosis vaccine enhances the ability of a recombinant strain to protect against Mycobacterium tuberculosis.
The immune response to tuberculosis is often described as a 'double-edged sword', as it protects the host against disease but also assists the pathogen by causing the tissue damage required for effective transmission. The notion of a double-edged sword has attractive poetic resonance but is less than satisfactory as a conceptual platform for the rational design of improved vaccines and immunodiagnostic reagents.
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