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Nature Medicine 9, 513 - 514 (2003)
doi:10.1038/nm0503-513
Cisplatin and the sensitive cell
Grover C. Bagby1 & Susan B. Olson1
- OSHU Cancer Institute, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA e-mail: grover@ohsu.edu and e-mail: olsons@ohsu.edu
Abstract
Epigenetic suppression of FANCF, a member of the Fanconi anemia gene family, is now implicated in some ovarian cancers. Might this suppression explain the sensitivity of such cancers to the cross-linking agent cisplatin (pages 568–574)?
Cancer cells are genetically unstable, often exhibiting complex karyotypes that include large deletions, insertions and unbalanced translocations of chromosomal material. Such cytogenetic findings typify the most aggressive and invasive malignancies.
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