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Nature Medicine 9, 508 - 509 (2003)
doi:10.1038/nm0503-508
Calcium and heart failure: the cycle game
Kenneth R. Chien1, John Ross Jr.1 & Masahiko Hoshijima1
- University of California, San Diego Institute of Molecular Medicine, UCSD School of Medicine, La Jolla, California, USA
Correspondence to: Kenneth R. Chien1 e-mail: kchien@ucsd.edu
Abstract
Three new studies examine how a regulator of calcium homeostasis contributes to heart failure in humans and mice.
Unraveling complex human diseases and identifying therapeutic targets often occurs through a cycle of discovery, moving from initial clinical insights, to experimental models and back to clinical studies. A trio of recent papers1, 2, 3 provides a prime example of this cycle.
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