We studied the role of NF-B in acute inflammation caused by gut ischemia-reperfusion through selective ablation of IB kinase (IKK)-, the catalytic subunit of IKK that is essential for NF-B activation. Ablation of IKK- in enterocytes prevented the systemic inflammatory response, which culminates in multiple organ dysfunction syndrome (MODS) that is normally triggered by gut ischemia-reperfusion. IKK- removal from enterocytes, however, also resulted in severe apoptotic damage to the reperfused intestinal mucosa. These results show the dual function of the NF-B system, which is responsible for both tissue protection and systemic inflammation, and underscore the caution that should be exerted in using NF-B and IKK inhibitors.
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B inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
B in acute inflammation caused by gut ischemia-reperfusion through selective ablation of I
, the catalytic subunit of IKK that is essential for NF-
