 | Figure 3
Nature Medicine
9, 448 - 452 (2003)
Published online: 17 March 2003; | doi:10.1038/nm840
Neuropathology of human Alzheimer disease after immunization with amyloid- peptide: a case reportJames A.R. Nicoll, David Wilkinson, Clive Holmes, Phil Steart, Hannah Markham
& Roy O. Weller | | | | Figure 3. Meningoencephalitis and infiltration of cerebral white matter by macrophages.
a−h, Leptomeningeal infiltrate of lymphocytes stained with H&E (a) and immunostained with a T-lymphocyte antibody (CD3; b). No B lymphocytes were detected (CD79a; c). d−h, Area adjacent to (c) showing T-lymphocyte (CD3-positive) aggregation around meningeal blood vessels. Meningeal lymphocytes are predominantly CD8-negative (e) and CD4-positive (f). Lymphocytes within the cerebral neocortex are also predominantly CD8-negative (g) and CD4-positive (h). i, Vacuolation and rarefaction of myelinated fibers in the cerebral white matter. j, Infiltration of cerebral white matter by CD68-immunoreactive macrophages.
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