 | Figure 1
Nature Medicine
9, 448 - 452 (2003)
Published online: 17 March 2003; | doi:10.1038/nm840
Neuropathology of human Alzheimer disease after immunization with amyloid- peptide: a case reportJames A.R. Nicoll, David Wilkinson, Clive Holmes, Phil Steart, Hannah Markham
& Roy O. Weller | | | | Figure 1. Distribution and quantitation of A pathology.
a, MRI scan at the time of acute illness, showing widespread signal alteration in cerebral white matter. b, Corresponding granular change in cerebral white matter seen in a coronal slice of the cerebral hemispheres at post-mortem examination. c, Patches of A plaques largely restricted to deep cortical laminae in the cingulate gyrus and medial frontal gyrus (immunized case). d, Absence of A plaques from parietal neocortex of the immunized case, with persistent vascular amyloid (CAA). e and f, Relatively uniform distribution of A plaques in corresponding regions of cerebral cortex in unimmunized AD. g and h, Quantitative image analysis showing plaque density (plaques/mm2; g) and A load (h). For the immunized case in the medial frontal gyrus (c), values were within the range of unimmunized Alzheimer's disease. In contrast, the plaque density and A load of the immunized case was lower than in unimmunized AD in the cingulate gyrus, and the inferior, middle and superior temporal gyri.  , immunized case; open shapes, 7 individual unimmunized AD cases.
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