The power of small RNAs to shut down specific gene activities has now been brought to bear on an animal model of hepatitis. Mice infused with an siRNA against a cell death receptor recover liver function after experimentally induced injury (pages 347–351).
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Change history
27 March 2003
This was incorrect in in print. The request to make the change before a print erratum is published was approved by Linda Miller. Replaced Figure 1 as per the note.
Notes
NOTE: In the version of this article initially published online and in print, Figure 1 was incorrect. The hydroxyl and phosphate groups were incorrectly placed on the siRNA duplexes. This mistake has been corrected in the HTML version. This correction has been appended to the PDF and print versions.
References
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Wajant, H. The Fas signaling pathway: more than a paradigm. Science 296, 1635–1636 (2002).
Zhang, H. et al. Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nat. Biotechnol. 18, 862–867 (2000).
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Zamore, P., Aronin, N. siRNAs knock down hepatitis. Nat Med 9, 266–267 (2003). https://doi.org/10.1038/nm0303-266
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DOI: https://doi.org/10.1038/nm0303-266
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