Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Arrhythmias of the heart: beyond ion channels

Research on an inherited form of cardiac arrhythmia has now homed in on the elusive trigger of electrical instability in the heart. Aberrant calcium regulation emerges as a strong candidate.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Proposed role of ankyrin-B in membrane targeting of ion handling molecules in cardiac muscle.

References

  1. Mohler, P.J. et al. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature 421, 634–639 (2003).

    Article  CAS  Google Scholar 

  2. Bourguignon, L., Jin, H., Iida, N., Brandt, N. & Zhang, S. The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells. J. Biol. Chem. 268, 7290–7297 (1993).

    CAS  PubMed  Google Scholar 

  3. Tuvia, S., Buhusi, M., Davis, L., Reedy, M. & Bennett, V. Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. J. Cell Biol. 147, 995–1008 (1999).

    Article  CAS  Google Scholar 

  4. Zhou, D. et al. AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J. Cell Biol. 143, 1295–1304 (1998).

    Article  CAS  Google Scholar 

  5. Kass, R.S., Lederer, W.J., Tsien, R.W. & Weingart, R. Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. J. Physiol. (Lond) 281, 187–208 (1978).

    Article  CAS  Google Scholar 

  6. Fozzard, H.A. Afterdepolarizations and triggered activity. Basic Res. Cardiol. 87, 105–113 (1992).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marks, A. Arrhythmias of the heart: beyond ion channels. Nat Med 9, 263–264 (2003). https://doi.org/10.1038/nm0303-263

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0303-263

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing