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Nature Medicine 9, 263 - 264 (2003)
doi:10.1038/nm0303-263
Arrhythmias of the heart: beyond ion channels
Andrew R. Marks1
- Center for Molecular Cardiology, Departments of Medicine and Pharmacology, Columbia University College of Physicians and Surgeons, New York, New York, USA e-mail: arm42@columbia.edu
Abstract
Research on an inherited form of cardiac arrhythmia has now homed in on the elusive trigger of electrical instability in the heart. Aberrant calcium regulation emerges as a strong candidate.
Cardiac arrhythmias are among the most common causes of death in the developed world, yet the mechanisms that trigger the electrical instability in heart muscle that causes arrhythmias are not well understood. Moreover, the current treatments for arrhythmias are limited mainly to very expensive devices such as implantable defibrillators and pacemakers.
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