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Nature Medicine 9, 261 - 262 (2003)
doi:10.1038/nm0303-261

Kaposi virus scores cancer coup

Chris Boshoff1

  1. Cancer Research U.K. Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK e-mail: c.boshoff@ucl.ac.uk

Kaposi sarcoma herpesvirus (KSHV) seems to exploit almost every known cancer pathway to promote tumorigenesis. Activation of the canonical Wnt–beta-catenin pathway can now be added to its list of conquests (pages 300–306).

KSHV (also known as Kaposi sarcoma-associated herpesvirus) is the infectious cause of Kaposi sarcoma (KS) and certain lymphoproliferations1, 2. Because of the AIDS epidemic, KS is one of the most common cancers in sub-Saharan Africa, and globally the fourth most common cancer caused by infection—after gastric cancer (Helicobacter pylori), cervical cancer (human papillomavirus) and liver cancer (hepatitis viruses).

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