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Nature Medicine 9, 258 - 260 (2003)
doi:10.1038/nm0303-258
PAR1 signaling: more good than harm?
Wolfram Ruf1
- Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, USA e-mail: ruf@scripps.edu
Abstract
Two studies link signaling of the anticoagulant thrombomodulin–protein C pathway to successful implantation during pregnancy and protection from ischemic brain injury. The data call for a reassessment of the causes of pre-eclampsia, and also provide hope for a new type of stroke therapy (pages 331–337 and 338–342).
Blood clotting is a tightly controlled process counterbalanced by anticoagulant mechanisms. Disruption of this balance can lead to disorders including stroke, heart attack and thromboembolism.
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