Journal home
Advance online publication
Current issue
Press releases
Guide to authors
Online submissionOnline submission
For referees
Free online issue
Contact the journal
Reprints and permissions
About this site
For librarians
NPG Resources
Nature Reviews
Nature Immunology
Nature Cell Biology
Nature Genetics
Nature Conferences
Dissect Medicine
NPG Subject areas
Clinical Medicine
Drug Discovery
Earth Sciences
Evolution & Ecology
Materials Science
Medical Research
Molecular Cell Biology
Browse all publications
Nature Medicine  9, 343 - 346 (2003)
Published online: 10 February 2003; | doi:10.1038/nm833

Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120

Ronald S. Veazey1, Robin J. Shattock2, Melissa Pope3, J. Christian Kirijan1, Jennifer Jones3, Qinxue Hu2, Tom Ketas4, Preston A. Marx1, Per Johan Klasse5, Dennis R. Burton6 & John P. Moore4

1  Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, USA

2  Department of Infectious Diseases, St. George's Hospital Medical School, London, UK

3  Center for Biomedical Research, The Population Council, New York, New York, USA

4  Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA

5  Jefferiss Research Trust Laboratories, Wright-Fleming Institute, Imperial College, London, UK

6  Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA

Correspondence should be addressed to John P. Moore
A topical microbicide reduces the probability of virus transmission when applied to the vagina or rectum of a person at risk of sexually acquiring HIV-1 infection1, 2, 3. An effective microbicide could significantly reduce the global spread of HIV-1, particularly if women were able to use it covertly to protect themselves. A microbicide could target the incoming virus and either permanently inactivate it or reduce its infectivity, or it could block receptors on susceptible cells near the sites of transmission1, 2, 3. We describe here how vaginal administration of the broadly neutralizing human monoclonal antibody b12 can protect macaques from simian-human immunodeficiency virus (SHIV) infection through the vagina. Only 3 of 12 animals receiving 5 mg b12 vaginally in either saline or a gel and then challenged vaginally (up to 2 h later) with SHIV-162P4 became infected. In contrast, infection occurred in 12 of 13 animals given various control agents under similar conditions. Lower amounts of b12 were less effective, suggesting that protection was dose dependent. These observations support the concept that viral entry inhibitors can help prevent the sexual transmission of HIV-1 to humans.

These links to content published by NPG are automatically generated

Microbicides: a new approach to preventing HIV and other sexually transmitted infections
Nature Reviews Drug Discovery Review (01 Dec 2002)
 See all 2 matches for Reviews

IgG surfaces as an important component in mucosal protection
Nature Medicine News and Views (01 Feb 2000)
HIV-1 neutralizing antibodies: How full is the bottle?
Nature Medicine News and Views (01 Feb 1999)

Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
Nature Medicine Article (01 Feb 2000)
Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes
Nature Medicine Article (01 Nov 2001)
 See all 6 matches for Research

Previous | Next
Table of contents
Full textFull text
Download PDFDownload PDF
Send to a friendSend to a friend
Competing financial interests
Figures & Tables
Export citation

Search buyers guide:

Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | Reprints and permissions | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©2003 Nature Publishing Group | Privacy policy