Metabolism Branch, Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland tawald@helix.nih.gov
Harnessing the immune system to treat chronic infectious diseases or cancer is a major goal of immunotherapy. Among others, impediments to this aim include host failure to identify tumor antigens, tolerance to self and negative immunoregulatory mechanisms. But with recent progress, active and passive immunotherapy are proving themselves as effective therapeutic strategies.