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Nature Medicine  9, 258 - 260 (2003)
doi:10.1038/nm0303-258

PAR1 signaling: more good than harm?

Wolfram Ruf

Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, USA ruf@scripps.edu

Two studies link signaling of the anticoagulant thrombomodulin−protein C pathway to successful implantation during pregnancy and protection from ischemic brain injury. The data call for a reassessment of the causes of pre-eclampsia, and also provide hope for a new type of stroke therapy (pages 331−337 and 338−342).

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The thrombomodulin–protein C system is essential for the maintenance of pregnancy
Nature Medicine Article (01 Mar 2003)

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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