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Nature Medicine 9, 168 - 169 (2003)
doi:10.1038/nm0203-168
eLiXiRs for restraining inflammation
Mason W. Freeman1 & Kathryn J. Moore1
- Lipid Metabolism Unit Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts, USA
Correspondence to: Mason W. Freeman1 e-mail: freeman@frodo.mgh.harvard.edu
Abstract
New data implicate the LXRs, a class of nuclear hormone receptors, in reducing inflammation. When activated, these receptors ease inflammation in three mouse models. The results are relevant to atherosclerosis, Alzheimer disease, sepsis and other inflammatory disorders (pages 213–219).
For decades, the activation of inflammatory responses by lipids has interested investigators working on a wide variety of human diseases. Exogenous lipids, derived from the walls of microbial pathogens, and endogenous lipids, generated from the oxidation of fatty acids and cholesterol, can both activate cells of the immune system and stimulate potent pro-inflammatory events.
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and RXR
ligand-binding domains in a fully agonistic conformation