Efficiently defending a host from repeat invasions by the same pathogen requires a lasting B-cell response. The identification of a molecule that keeps B cells prepared may help to explain some immune disorders and lead to improved vaccines.
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Renee Lucas
References
Clark, E.A. & Ledbetter, J.A. How B and T cells talk to each other. Nature 367, 425–428 (1994).
McHeyzer-Williams, M.G. & Ahmed, R.B cell memory and the long-lived plasma cell. Curr. Opin. Immunol. 11, 172–179 (1999).
Crotty, S., Kersh, E.N., Cannons, J., Schwartzberg, P.L. & Ahmed, R. SAP is required for the generation of long-term humoral immunity. Nature 421, 282–287 (2003).
Li, C., Iosef, C., Jia, C.Y., Han, V.K. & Li, S.S. Dual functional roles for the XLP syndrome gene product SAP/SH2D1a in signaling through the SLAM family of immune receptors. J. Biol. Chem.; published online 27 November 2002 (10.1074/jbc.M206649200).
Sidorenko, S.P. & Clark, E.A. The dual-function CD150 receptor subfamily: the viral attraction. Nat. Immunol. 4, 19–24 (2003).
Gaspar, H.B., Sharifi, R., Gilmour, K.C. & Thrasher, A.J. X-linked lymphoproliferative disease: clinical, diagnostic and molecular perspective. Br. J. Haematol. 119, 585–595 (2002).
Morra, M. et al. Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. Blood 98, 1321–1325 (2001).
Grierson, H.L., Skare, J., Hawk, J., Pauza, M. & Purtilo, D.T. Immunoglobulin class and subclass deficiencies prior to Epstein-Barr virus infection in males with X-linked lymphoproliferative disease. Am. J. Med. Genet. 40, 294–297 (1991).
MacLennan, I.C.M. et al. Memory B-cell clones and the diversity of their members. Semin. Immunol. 9, 229–234 (1997).
Szomolanyi-Tsuda, E. & Welsh, R.M. T cell–independent antiviral antibody responses. Curr. Op. Immunol. 10, 431–435 (1998).
Wu, C. et al. SAP controls T cell responses to virus and terminal differentiation to TH2 cells. Nat. Immunol. 2, 382–384 (2001).
Czar, M.J. et al. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/SAP. Proc. Natl. Acad. Sci. USA 98, 7449–7454 (2001).
Borrow, P. et al. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J. Exp. Med. 183, 2129–2142 (1996).
Fearon, D.T. & Carroll, M.C. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Ann. Rev. Immunol. 18, 393–422 (2000).
Chen, Z. et al. Humoral immune responses in Cr2−/− mice: enhanced affinity maturation but impaired antibody persistence. J. Immunol. 164, 4522–4532 (2000).
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Welsh, R., Stepp, S. & Szomolanyi-Tsuda, E. B cell memory: Sapping the T cell. Nat Med 9, 164–166 (2003). https://doi.org/10.1038/nm0203-164
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DOI: https://doi.org/10.1038/nm0203-164
